氯吡格雷治疗微栓子阳性脑梗死患者二年随访报告  

Effect of Therapy by Clopidogrel on the Occurrence of Micro-Emboli Signals (MES) and Cerebral Ischemic:A Follow-up Study of 220 Cases

作　　者：单梅芳[1] 黄志东[2] 朱银圣[1] 顾承志[2] 黄怀宇[2] 

机构地区：[1]江苏省如皋市人民医院神经内科,如皋226500 [2]南通大学第二附属医院神经内科

出　　处：《微循环学杂志》2010年第1期44-46,共3页Chinese Journal of Microcirculation

摘　　要：目的:探讨经颅多普勒(TCD)检测氯吡格雷治疗脑梗死患者对微栓子(MES)的干预作用。方法:将220例MES阳性脑梗死患者分为普通组(对照组)、氯吡格雷治疗组(治疗组)来研究氯吡格雷治疗对MES的干预作用并随访二年后的脑血管事件发生情况。结果:治疗组出院后半年内、半年至1年内、1年至2年内MES阳性率低于对照组(P<0.01),缺血性脑血管事件发生率少于对照组(P<0.05)。结论:氯吡格雷可稳定动脉粥样硬化斑块,减少MES形成,有效预防缺血性脑血管事件的发生。Objective:To investigate the effect Clopidogrel therapy on the occurrence or disappearance of micro-emboli signals(MES)in cerebral ischemic patients by Transcranial Doppler(TCD)detection.Method:220 MES positive patients were divided into 2 groups:control group and therapy group.MES were measured at different time point.Results:MES positive rate and cerebral ischemic rate of Clopidogrel were lower than control group at different time point(P<0.05).Conclusion:MES positive patients accept Clopidogrel capsul combined intervention would stabilize carotid plaques,have a decreased MES positive rate,decrease the incidents of cerebral ischemic.

关 键 词：脑梗死患者 氯吡格雷 微栓子 随访报告 阳性 治疗 缺血性脑卒中 经颅多普勒 

分 类 号：R743[医药卫生—神经病学与精神病学] R973.2[医药卫生—临床医学]