多型短指软珊瑚Sinularia polydactyla(Ehreberg)中的氧化甾醇  

Analysis of Oxygenated Sterols from the Soft Coral Sinularia polydactyla (Ehreberg)

作　　者：张翠仙[1] 张广文[2] 何细新[1] 林朝展[1] 赵钟祥[1] 祝晨蔯[1] 苏镜娱[3] 曾陇梅[3] 

机构地区：[1]广州中医药大学中药学院,广州510006 [2]暨南大学食品科学与工程系,广州510632 [3]中山大学化学与化学工程学院,广州510275

出　　处：《中药新药与临床药理》2010年第1期70-72,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金资助(29932030);广东省师资队伍建设科研启动经费(A1033025)

摘　　要：目的充分利用我国南海药用资源,发现软珊瑚Sinularia polydactyla(Ehreberg)中抗肿瘤和抗炎活性成分。方法采用硅胶柱层析,物理常数比较和波谱方法(NMR、MS等)确定化合物的结构。结果从采自海南三亚海域的多型短指软珊瑚Sinularia polydactyla(Ehreberg)乙醇提取物的乙酸乙酯部位分离得到3个甾体类化合物。通过物理数据比较和波谱方法确定其结构分别是:24-亚甲基-9,11-开环胆甾-5-烯-3β,11-二醇-9-酮(1),9,11-开环麦角甾-5-烯-3β,11-二醇-9-酮(2),麦角甾-3β,5α,6β-三醇(3)。结论化合物1,2,3均首次从此种软珊瑚中得到。体外活性试验表明均具有抗炎活性和显著的细胞毒活性。Objective For utilization of the medicinal sources from South China Sea, antitumour and antiflammaty active constituents of Sinularia polydactyla （Ehreberg） were analyzed. Methods On the basis of to indification of The structures of the active constituents of Sinularia polydactyla （Ehreberg） were identified by silica gel column chromatography, spectroscopic methods （such as NMR and MS ） and physical constant comparison. Results Three sterols were first isolated from the ethanol - exacts of soft coral Sinularia polydactyla collected from Sanya Bay, Hainan Island, and their structures were identified as 24 - methylene - 9, 11 - secocholest - 5 - en - 3β, 11 - diol - 9 - one （1）, 9, 11 - secoergost- 5-en-3β, 11-diol- 9- one （2）, and ergostane 3β, 5α, 6β- triol （3）. Conclusion Comonents 1, 2, and 3 are isolated from the soft coral for the first time, and exert potent cytotoxic and anti - inflammatory actions.

关 键 词：软珊瑚 SINULARIA polydactyla 氧化断甾醇 生理活性 

分 类 号：R284.1[医药卫生—中药学]