肝细胞癌患者1.5T氢质子磁共振波谱分析  

Proton MR spectroscopy of hepatocellular carcinoma patients at 1.5 Tesla

作　　者：陈鹏[1] 赵卫东[1] 张红宇[1] 秦惠娟[1] 刘帅[1] 

机构地区：[1]山西医科大学第二医院影像科,山西太原030001

出　　处：《中国癌症杂志》2010年第1期55-58,共4页China Oncology

摘　　要：背景与目的:磁共振波谱成像是目前唯一能无创性检测活体器官和组织代谢物成分,并进行半定量或定量分析的磁共振成像技术。本研究旨在通过对活体肝脏进行单体素氢质子磁共振波谱(1H-MRS)扫描,分析健康人肝脏、肝硬化患者再生结节聚集区和肝硬化后肝癌患者肝癌代谢物的变化特点。方法:对20例健康志愿者(对照组)、25例肝硬化(肝硬化组)和23例肝硬化后肝癌(肝癌组)患者行1H-MRS扫描,观察波谱曲线的特征;测量胆碱复合物(Cho)、脂肪亚甲基(Lip2)峰高及Cho/Lip2比值,并对结果进行记录和比较。结果:波谱检查成功率约为88.2%(60/68);3个研究组Lip2峰高差异有统计学意义;两两比较,对照组与肝癌组Lip2峰高差异有统计学意义(P<0.05),对照组与肝硬化组、肝硬化组与肝癌组Lip2峰高差异均无统计学意义(P>0.05);3组人群Cho峰高、Cho/Lip2比值,两两比较,差异均有统计学意义(P<0.05)。结论:1H-MRS可无创性反应肝脏的代谢变化,可以为肝细胞癌的诊断及与肝硬化再生结节的鉴别提供相关信息。Background and purpose：Magnetic resonance spectroscopy is currently the only non-invasive magnetic resonance imaging technique which can detect metabolite composition of live organ and tissue and also conduct semi-quantitative or quantitative analysis. We analyzed the characteristics of metabolic changes among normal liver, cirrhosis regenerative nodule and liver cancer on the background of cirrhosis by voxel proton MR spectroscopy at 1.5 Tesla. Methods：20 healthy volunteers （control group）, 25 cirrhosis （cirrhosis group） and 23 hepatocellular carcinoma after cirrhosis （HCC group） patients were our candidates. The characteristics of spectra of ^1H-MRS were observed. The height and ratio of choline complex （Cho） and lipid methylene （Lip2） were recorded and the results were compared among the groups. Results：The success rate of ^1H-MRS was about 88.2% （60/68）. There were statistically significant differences among the heights of Lip2 peak of the three groups, and also between that of the control group and the group of liver cancer. But there were no significant differences between that of control group and cirrhosis group, cirrhosis group and liver cancer group. The comparison of the height of Cho peak and the ratio of Cho/Lip2 showed statistically significances both among the three groups and between each other. Conclusion：The metabolic changes of the liver could be shown non-invasively by ^1H-MRS, which could be useful for differential diagnosis or diagnosis of cirrhosis regenerative nodule and HCC.

关 键 词：磁共振氢质子波谱 肝癌 肝硬化 

分 类 号：R730.42[医药卫生—肿瘤] R735.7[医药卫生—临床医学]