肺癌肉瘤临床特征对生存情况的影响  

Analysis for the prognosis of patients with pulmonary carcinosarcoma

作　　者：周琪[1] 姜格宁[2] 杨廷松[1] 段亮[2] 刘明[2] 唐一飞[1] 

机构地区：[1]上海市市东医院胸外科,上海200438 [2]同济大学附属上海市肺科医院胸外科,上海200433

出　　处：《中国癌症杂志》2010年第1期59-61,共3页China Oncology

摘　　要：背景与目的:癌肉瘤(carcinosarcoma,CS)是指一种在同一肿瘤中存有癌和肉瘤两种成分的混合性恶性肿瘤,肺癌肉瘤更是一种罕见的肺部恶性肿瘤,5年生存率低。本研究的目的是探讨肺癌肉瘤的临床特征对生存情况的影响。方法:通过收集64例肺癌肉瘤患者的临床资料,回顾性分析了患者的性别、年龄、p-TNM分期、肿瘤位置、化疗和手术方式等因素对预后的影响。结果:64例肺癌肉瘤患者术后5年生存率为14.1%。早期(Ⅰ、Ⅱ)和晚期(Ⅲ、Ⅳ)组5年生存率分别为28.6%和2.8%,差异有统计学意义(P=0.003);全肺切除、肺叶切除及姑息性手术组的5年生存率分别为33.3%、9.5%和0,差异有统计学意义(P=0.039)。结论:p-TNM分期、手术方式与肺癌肉瘤的生存情况关系密切。早期发现,早期行根治性手术,对延长患者的生存非常有意义。Background and purpose：Carcinosarcoma of the lung is a rare malignant pulmonary neoplasm, which including epithelial and parenchymal malignant structure with a poor prognosis. The purpose of this study was to describe the clinicopathologic characteristics and the survival of pulmonary carcinosarcoma. Methods：From Jan. 1980 to Dec. 2006, 64 patients with pulmonary carcinosarcoma who underwent surgical treatment were retrospectively analyzed. Results：The overall 5-year survival rate of the patients was 14.1%. There was significant difference between stage Ⅰ/Ⅱ and stage Ⅲ/Ⅳ disease （28.6% vs 2.8%, P=0.003）, respectively. The 5-year survival rates of lobectomy, pneumonectomy and palliative resection were 33.3%, 2.8% and 0% （P=0.003）, respectively. Conclusion： p-TNM and operative pattern were correlated with survival. Early diagnosis and radical operation are important to the survival of the patients with pulmonary carcinosarcoma.

关 键 词：肺癌肉瘤 临床特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]