早期应用丹参川芎嗪注射液对局灶性脑缺血-再灌注损伤大鼠血-脑屏障通透性的影响  

Effect of Salvia Ligustrazine Injection on the permeability of blood brain barrier of focal cerebral ischemic-reperfusion injured rats

作　　者：牛文华[1] 牛小媛[1] 刘凤琴[1] 

机构地区：[1]山西医科大学附属第一医院神经内科,山西太原030001

出　　处：《中国医药导报》2010年第5期12-13,共2页China Medical Herald

摘　　要：目的:观察丹参川芎嗪注射液对脑缺血-再灌注(ischemic-reperfusion,IR)损伤大鼠血-脑屏障(blood brain barrier,BBB)通透性的影响。方法:荧光分光光度法测定大脑中动脉缺血-再灌注大鼠各个时间点伊文思蓝含量,在伊文思蓝漏出最多的时间点,比较丹参川芎嗪注射液组和盐水组伊文思蓝的含量。结果:再灌注后3h脑组织中伊文思蓝含量开始增加,24h达最高;在24h时给予丹参川芎嗪注射液,伊文思蓝含量低于盐水组(P<0.05)。结论:丹参川芎嗪注射液可以降低脑缺血-再灌注后BBB的通透性,对大鼠局灶性脑缺血-再灌注损伤有保护作用。Objective： To observe the effect of Salvia Ligustrazine Injection （SLI） on the permeability of blood-brain barrier （BBB） in rats. Methods： The cerebral artery ischemia-reperfusion model of Wistar rats were prepared by intraluminal middle, and the EB of brain tissue at different time points was determined by using quantitative fluorescence spectrophotometric determination. SLI treatment group and saline group were done at the point of the peak of permeability of BBB, and the effect of SLI on the permeability of BBB was observed. Results： EB began to increase 3 h after reperfusion 2 h after ischemia, and reached peak at 24 h. SLI was given to interfere 24 h after reperfusion, the amount of EB of SLI-treatment group was significantly lower than that of saline group （P〈0.05）. Conclusion： SLI can effectively prevent the permeability of BBB, and it shows a protective effect on cerebral local ischemia-reperfusion iniurv of rats.

关 键 词：丹参川芎嗪注射液 脑缺血-再灌注 血-脑屏障 伊文思蓝 

分 类 号：R-33[医药卫生]