血清CA15-3和B-AKP检测在乳腺癌术后骨转移显像诊断中的应用  

Application of Measurements of Serum CA15-3 and B-AKP in Diagnosis of Bone Metastasis in Patients with Post-operative Mammary Cancer

作　　者：刘雁[1] 张霞[1] 袁士强[1] 

机构地区：[1]聊城市第二人民医院核医学科,山东聊城252601

出　　处：《标记免疫分析与临床》2010年第1期20-22,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：为探讨血清CA15-3和B-AKP在乳腺癌术后骨转移显像诊断中的应用,对92例乳腺癌术后患者的核素骨显像结果、血清CA15-3和B-AKP水平进行回顾性研究。结果显示:①血清CA15-3和B-AKP的值随着骨转移分期的增高而逐步升高,且有显著性差异(P<0.01);②血清CA15-3和B-AKP与骨转移灶的数目呈正相关;③血清CA15-3>25U/mL时,骨转移的阳性率为63.3%,血清CA15-3<25U/mL时,骨转移的阴性预测值为94.5%;血清B-AKP>20U/L时,骨转移的阳性率为59.6%,B-AKP<20U/L时,骨转移的阴性预测值为73.5%;当血清CA15-3<25U/mL同时B-AKP<20U/L时,骨转移的阴性预测值为100%。结论:血清CA15-3和B-AKP测定在乳腺癌术后骨显像诊断中具有重要的应用价值。To evaluate the diagnosis value of serum CA15-3 and B-AKP measurements in diagnosis of bone metastasis images in patients with post-operative mammary cancer,retrospective study on the bone scan images and serum CA15-3 and bone alkaline phosphatase（B-AKP） levels were performed in 92 patients with confirmed post-operative mammary gland cancer.The results showed that the serum levels of CA15-3 and B-AKP were increased step by step significantly along with the advancement of bone metastatic grading from M0 to M3（P〈0.01）.The serum levels of CA15-3 and B-AKP were positively correlated with the number of bone metastasis.The positive rate of bone metastasis was 63.2% with serum CA15-3 more than 25U/mL;and the negative predictive value of bone metastasis was 94.5% with serum CA15-3 less than 25U/mL.The positive rate of bone metastasis was 59.6% with serum B-AKP levels more than 20U/L;and the negative predictive value of bone metastasis was 73.5% with serum B-AKP levels less than 20U/L.The negative predictive value of bone metastasis was 100% with serum CA15-3 less than 25U/mL and serum B-AKP levels less than 20U/L.The combined measurement of the serum CA15-3 and B-AKP levels would play an important role in diagnosis of bone scan images in patients with post-operative mammary cancer.

关 键 词：乳腺癌 骨转移 骨显像 乳腺癌糖类抗原15-3 骨特异性碱性磷酸酶 

分 类 号：R737.9[医药卫生—肿瘤]