急性脑梗死患者血清中载脂蛋白CII水平的动态变化  

DYNAMIC CHANGES AND SIGNIFICANCE OF SERUM Apo-CII LEVEL IN PATIENTS WITH ACUTE CEREBRAL INFARCT

作　　者：檀国军[1] 曹彩生 蔺辉前[1] 张建娥[1] 宋文杰[3] 

机构地区：[1]河北医科大学第二医院神经内科,河北石家庄050000 [2]河北省深泽县医院神经内科,河北深泽052560 [3]河北医科大学第二医院检验科,河北石家庄050000

出　　处：《河北医科大学学报》2010年第1期24-26,共3页Journal of Hebei Medical University

基　　金：河北省卫生厅科技攻关项目(05120)

摘　　要：目的了解载脂蛋白CII(apolipoprotein-CII,Apo-CII)在急性脑梗死病程中的动态变化,探讨其在脑梗死发病过程中的作用及意义。方法动态测定62例1d内发病的脑梗死患者1、7、14 d血清中Apo-CII含量,并分析与病程、病情的相关性。结果所有患者在发病1d时Apo-CII水平最高,以后随着病程的延长血清Apo-CII含量逐渐下降,并与美国国立卫生研究院脑卒中量表评分呈显著正相关(r=0.981,P<0.01),与Barthel指数无直线相关关系(r=-0.909,P>0.05)。结论 Apo-CII升高是脑梗死急性发病的重要因素之一,血清ApoC-II水平改变可能比血清胆固醇异常更早、更敏感的反映脂质代谢异常状态。积极控制脂代谢紊乱对脑梗死的防治具有重要作用。Objective To dynamically measure serum apolipoprotein-CII（Apo-CII） content in patients with acute cerebral infarct（ACI）,and evaluate its role. Methods Serum Apo-CII level in 62 patients with ACI were measured on 1,7,14 d. The relationship between serum Apo：CII level and ACI course,NIHSS score were analyzed. Results Serum Apo-CII level was the highest on 1 d of ACI, and then decreased gradually along with course. The change direction of serum Apo-CII level correlated with NIHSS （ r = 0. 981, P 〈0.01） ; There were no linear correlation between serum Apo-CII level and Barthel index（ r =-0. 909, P 〉0.05）. Conclusion Increase of serum Apo-CII level plays an important role in ACI incident; Apo-CII may be an earlier, more sensitiv.e index of reflecting turbulence of lipids metabolism than cholesterin. It may be a key therapeutic method to regulate the turbulence of lipids metabolism initiatively for preventing ACI attack.

关 键 词：梗塞 大脑中动脉 载脂蛋白C类 胆固醇 

分 类 号：R743.33[医药卫生—神经病学与精神病学]