腹腔灌注化疗治疗癌性腹水30例临床观察  

Clinical Effects of Abdominal Infusion for 30 Patients with Malignant Peritoneum Effusion

作　　者：郝杰 陈小玲 应江山 

机构地区：[1]上海市闸北区北站医院肿瘤内科,200070

出　　处：《实用癌症杂志》2010年第1期43-44,56,共3页The Practical Journal of Cancer

摘　　要：目的探讨腹腔灌注亚叶酸钙(CF)、5-氟尿嘧啶(5-Fu)、顺铂(DDP)治疗恶性肿瘤引起的癌性腹水的疗效及不良反应。方法对30例恶性肿瘤患者,予以腹腔穿刺放腹水,并腹腔灌注地塞米松5mg+生理盐水250ml,CF200mg+生理盐水250ml,DDP40mg+生理盐水500ml,5-Fu1000mg+生理盐水500ml,且配合全身化疗,每周1次,2次为1个疗程,间隔2周,观察疗效及不良反应。结果完全缓解13例,部分缓解12例,稳定3例,无效2例,治疗总有效率83.33%;生活质量有提高,6个月生存率66.67%,中位生存期7.6个月。主要毒性为消化道反应。结论腹腔灌注CF、5-Fu及DDP,配合全身化疗治疗癌性腹水疗效显著,不良反应轻,可明显改善患者生活质量,是晚期恶性肿瘤姑息治疗的1种有效方法。Objective To evaluate the clinical efficacy and of abdominal infusion with leucovorin （CF） ,5-fiuorouracil （5-Fu）, and cisplatin （DDP） for the patients with malignant peritoneum effusion. Methods 30 patients with malignant peritoneum effusion were treated with abdominal infusion with CF （200 mg） ,5-Fu （1 000 mg）, and DDP （40 mg）. All patients were treated with systemic chemotherapy. The abdominal infusion was given once a week for 2 weeks, and repeated with an interval of 2 weeks. Results The overall response rate was 83.33% , including complete response in 13 cases,partial response in 12 cases, stable disease in 3 eases, and progressive disease in 2 eases. The quality of life was improved and 6-month survival rate was 66.67% with a median survival time of 7.6 months. The main side effects were gastrointestinal toxicities. Conclusion The combination of abdominal infusion （CF,5-Fu,and DDP） and systemic chemotherapy was effective and safe for the patients with malignant peritoneum effusion.

关 键 词：腹腔灌注 癌性腹水 亚叶酸钙 5-氟尿嘧啶 顺铂 

分 类 号：R730.6[医药卫生—肿瘤]