嗅神经母细胞瘤36例临床分析  

Clinical Analysis of 36 Cases of Esthesioneuroblastoma

作　　者：龚巧英[1] 吴新生[1] 

机构地区：[1]江西省肿瘤医院放疗科,330029

出　　处：《实用癌症杂志》2010年第1期68-70,共3页The Practical Journal of Cancer

摘　　要：目的探讨嗅神经母细胞瘤的诊断、治疗及预后。方法回顾性分析36例嗅神经母细胞瘤患者的临床资料;根据Kadish分期:A期6例,B期12例,C期18例。治疗方法:单纯手术4例;单纯放疗10例;综合治疗22例;其中12例手术治疗+放疗;4例放疗+化疗;6例手术+放疗+化疗。结果5年生存率为33.3%(12/36),A期5年生存率为50.0%(3/6),B期5年生存率为58.3%(7/12),C期5年生存率为11.1%(2/18),单纯手术5年生存率为50.0%(2/4),单纯放疗5年生存率为40.0%(4/10);综合治疗5年生存率为27.3%(6/22);局部控制率为58.3%(19/36),远处转移率为44.4%(16/36),12例死于远处转移,5例死于局部复发。早期(A,B期)患者的生存率高于晚期患者(C期)(χ2=4.08,0.025<P<0.05)。结论早期治疗及综合治疗可改善嗅神经母细胞瘤患者生存率。手术加放疗有助于提高嗅神经母细胞瘤的局部控制率。远处转移是影响其预后的主要因素。Objective To study the diagnosis, treatment policy and prognosis in patients with esthesioneuroblastoma. Methods Data of 36 patients with esthesioneuroblastoma were retrospectively reviewed. According to the Kadish system, the patients were staged as follows： stage A ,6 cases; stage B, 12 cases; and stage C, 18 cases. Four patients were treated with surgery alone, 10 irradiation alone ,and 12 combination with surgery and radiation,4 combination with radiation and chemotherapy and 6 surgery,radiation and chemotherapy. Results The overall 5-year survival rate was 33.3% （12/36）. The survival rates for stage A,B,and C were 5010% （3/6） ,58.3% （7/12） ,and 11.1% （2/18） respectively. The survival rates for surgery alone,radiation alone and combined therapy were 50.0% （2/4） ,40.0% （4/10）, and 27.3% （6/22） , respectively. The local control rate and distant metastasis rate were 58.3% （19/36） and 44.4% （16/36）, respectively. There were 12 patients died of distant metastasis and 5 patients died of local recurrence. The survival rate in patients with early stage（ A ＋ B） esthesioneuroblastoma was significantly better than that in patients with advances stage C. Conclusion Early detection and combined therapy were important to improve survival rate. The combined therapy with radiation therapy and surgery could help to achieve excellent local control. Distant metastasis was an important factor which affected the prognosis of the patients.

关 键 词：成感觉神经细胞瘤 嗅觉 嗅神经疾病 神经系统肿瘤 

分 类 号：R739.4[医药卫生—肿瘤]