肿瘤转移抑制基因KAI1在上皮性卵巢癌中的表达及相关性研究  

Study of Expression and Significance about Metastasis Suppressor Gene KAI1 in Epithelial Ovarian Cancer

作　　者：张毅芳[1] 林国志[1] 

机构地区：[1]泰山医学院,山东泰安271000

出　　处：《社区医学杂志》2010年第3期1-3,共3页Journal Of Community Medicine

摘　　要：目的探讨肿瘤转移抑制基因KAI1在上皮性卵巢癌中的表达,分析它与卵巢癌临床病理资料之间的关系,探索它在卵巢癌发生、发展过程中的作用。方法应用免疫组织化学链真菌抗生物素-过氧化物酶连接法(S-P法)对上皮性卵巢癌组织中KAI1蛋白的表达情况进行检测,结合肿瘤的病理学行为和临床随访资料进行综合分析。结果KAI1蛋白在上皮性卵巢癌中的阳性与在正常卵巢组织、良性上皮性卵巢肿瘤组织中的表达比较差别均有统计学意义(P<0.05)。KAI1蛋白在上皮性卵巢癌组中的表达与临床分期、组织学分级、有无淋巴结转移及有无腹水密切相关(P<0.05),而与年龄、病理类型无关(P>0.05)。结论KAI1蛋白有望成为上皮性卵巢癌的早期诊断及病情监测的生物学指标,通过对这种蛋白表达的检测有助于筛选可能发生卵巢癌转移的高危人群,指导临床随诊和治疗。KAI1蛋白的表达与上皮性卵巢癌的演变和转移密切相关,检测其表达情况对判断肿瘤的分化、临床进展以及估计预后有一定的参考价值。Objective To investigate the expression of metastasis suppressor gene KAI1 in EOC. Methods Expression of KAll in 50 cases of EOC,20 cases of benign tumor and 15 cases of normal ovary tissue were detected immunohistochemically. The pathological featureand clinicalfollow - up data was also analysed. Results The expression of KAll in EOC and in the benign tumors were significant differences as well as in EOC and in normal ovary tissues（P 〈0.05 ,P 〈 0.05 ）. The expression of KAll was no significant differences in the benign tumors and in normal ovary tissues（ P 〉 0.05 ）. The expression of KAI1 in EOC is related with the histological grade, FIGO staging,lymphnode metastasis and cancerousascits（P 〈 0.05 ） ,but the expression is no related with the age and histologictype（P 〉 0.05）. Conclusion KAll may be new targets in the treatment of EOC. Monitoring the expression of KAI1 and E - cadherin will help to distinguish the high risk people of EOC and direct clinical follow - up treatment. Expressions of KAll otein is closely related with the malignant progression and metastasis of EOC, detacting the expression of them probably possesses clinical significance in evaluation of the differen- tiation and tumor progression and prediction of the prognosis in EOC.

关 键 词：转移抑制基因 卵巢癌 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]