疏肝导浊方对脂肪肝家兔的AST、ALT、ALP、NO、SOD和MDA的影响  

The effect of Shugandaozhuo medicine on AST,ALT,ALP,NO,SOD and MDA in rabbit with fatty liver

作　　者：王威[1] 江海涛[1] 史红[1] 刘友刚[1] 王超[1] 田维[1] 胡利民[1] 

机构地区：[1]天津中医药大学,教育部方剂学重点实验室,天津市药理学重点实验室,天津300193

出　　处：《天津中医药》2010年第1期9-11,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家科技部支撑计划;名优中成药大品种二次开发关键技术的研究项目(2007BA247B04)

摘　　要：[目的]观察疏肝导浊方对脂肪肝家兔肝功能及抗氧化作用的影响。[方法]采用高脂饲料喂饲家兔6周,诱导形成脂肪肝模型,实验分组为疏肝导浊方高、中、低(8、4、2g/kg)剂量组、东宝肝泰对照组、模型组和空白对照组,检测各组肝功能、超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)水平。[结果]模型组肝功能、SOD明显下降(P<0.05),MDA明显增加(P<0.01);疏肝导浊方中、低剂量组SOD明显升高(P<0.05)。[结论]疏肝导浊方可有效提高脂肪肝家兔的抗氧化作用。[Objective] To observe the effects of Shuogandaozhuo Medicine （dispersing stagnation of liver-Q and reducing the turbid pathogen, SM） on liver function and its anti-oxygenation in rabbits with fatty liver. [Methods] The fatty liver in rabbits was induced by feeding them with high caloric diet for six weeks. Sixty rabbits were randomly divided into six groups including the high-dose, middledose and low-dose SM groups, the Dongbaogantai group, the model group and the normal control group. The liver index （liver weight/body weight）, the amount of AST, ALT, ALP, NO, SOD and MDA in the serum were investigated after medication. [Results] The liver function and the amount of SOD decreased significantly （P〈0.05） in the model group with significant increasing of the MDA （P〈0.01）; Significant increase of SOD was found in the middle and low-dose of the SM group （P〈0.05）. [Conclusion] SM is effective for increasing anti-oxidation in rabbits with fatty liver.

关 键 词：脂肪肝 疏肝导浊方药 超氧化物歧化酶 丙二醛 一氧化氮 

分 类 号：R575.2[医药卫生—消化系统]