孤独症儿童与其他精神障碍儿童围生期危险因素比较  

Comparison of perinatal risk factors between patients with autism and other psychotic disorders

作　　者：郝晓楠[1] 张岱[1] 贾美香[1] 

机构地区：[1]北京大学精神卫生研究所(卫生部精神卫生学重点实验室),北京100083

出　　处：《中国心理卫生杂志》2010年第1期25-28,共4页Chinese Mental Health Journal

基　　金：国家高技术研究发展计划(863计划)资助(2006AA02Z195)

摘　　要：目的:比较孤独症与其他精神障碍儿童围生期危险因素之间的差异。方法:应用自制围生期危险因素调查表对197例孤独症儿童和93例其他精神障碍儿童进行回顾性调查。应用t检验和卡方检验分析两组儿童之间围生期危险因素的差异。结果:孤独症组围生期危险因素发生率高于其他精神障碍组(68%vs.51%,P=0.003),其母孕期感冒史及早产史发生率均高于其他精神障碍组(14.2%vs.6.5%,10.7%vs.3.2%;P=0.038,0.022);两组儿童在喂养方式上差异也有统计学意义(孤独症组母乳喂养、混合喂养、人工喂养的比例分别为67.7%、15.0%、17.3%,其他精神障碍组3种喂养方式的比例分别为48.3%、22.4%、29.3%;P=0.038)。结论:母孕期感冒、早产和喂养方式与孤独症发病可能有某种联系。Objective： To explore the possible specific perinatal risk factors in the development of autism through comparing the perinatal risk factors between patients with autism and other psychotic disorders. Methods： In this retrospective research, 197 cases with autism and 93 cases with other psychotic disorders were selected and assessed with the self-made scale of perinatal risk factors. Statistical analyses were performed using t test and Chisquare test. Results： Compared with the control group, the autistic subjects had a significantly higher frequency of the perinatal risk factors （ 51% vs. 68 %, P = 0. 003） , particularly the rate of catching a cold during their mothers pregnancy （14.2% vs. 6.5%, P=0.038） and the rate ofprematurity （10.7% vs. 3.2%, P=0.022） than the control subjects. Feeding methods was different between the two groups （ P = 0. 038 ） . Conclusion： Catching a cold during mothers＇pregnancy, prematurity and feeding methods may be related to the development of autisnm.

关 键 词：孤独症 围生期 高危因素 回顾性研究 

分 类 号：R749.94[医药卫生—神经病学与精神病学] R714.7[医药卫生—临床医学]