涎腺淋巴上皮癌临床病理观察  

Lymphoepithelial carcinoma of salivary gland:a cinicopathologic observation

作　　者：张伟[1] 唐仁泉[1] 刘媛媛[1] 刘东威[1] 张学义[1] 

机构地区：[1]抚顺矿务局总医院病理科,辽宁抚顺113008

出　　处：《现代肿瘤医学》2010年第2期279-281,共3页Journal of Modern Oncology

摘　　要：目的:探讨涎腺淋巴上皮癌的临床病理学特征和鉴别诊断。方法:对5例涎腺淋巴上皮癌的临床特征、组织学形态和免疫学表型进行观察。结果:3例肿瘤发生于耳垂下,2例发生于下颌下区。临床主要表现为局部包块,活动度差,伴有疼痛。组织学特点为肿瘤细胞较大,多角形、卵圆形,细胞核泡状,肿瘤细胞呈片状、岛状、索条状,间质为成熟的淋巴细胞和浆细胞。免疫组化:5例肿瘤细胞CK(pan)、EMA、EBV均为(+);而S-100、CgA、CD68、LCA、Vimentin、SMA均为(-);间质细胞CD3、CD20、CD43均为部分(+)。结论:涎腺淋巴上皮癌非常少见,是一种分化差,但是预后尚可的肿瘤,确诊依赖组织学和免疫组化检测。手术广泛全切和术后辅助放疗是本病的最佳治疗措施。Objective： To investigate the clinicopathological features of lymphoepithelial carcinoma of salivary gland and its diagnosis. Methods ： Clinical, morphologic and immunohistochemical representations were described in 5 cases of lymphoepithelial carcinoma of salivary gland. Results： The tumors were located at the underneath lobulus auricular subcutaneous in 3 cases, underneath lower jaw subcutaneous in 2 cases. The major clinical manifestations were focal phyma, range of the motion was bad and pain. Microscopically, the large tumor cells were polygonal or oval shape with vesicular nuclei, the tumor cells were arranged in sheets, strips and islands, mature lymphocytes and plasma cells in the stroma. Immunohistochemistry ：All 5 cases were positive for CK（pan） ,EMA and EBV;while other markers in- cluding S- 100, CgA, CD68, LCA, Vimentin and SMA, were all negative. Cells were focally positive for CD3, CD20 and CD43 in the stroma. Conclusion： Lymphoepithelial carcinoma of salivary gland is extremely rare. Although this disease is poorly diferentiated, the prognosis is not bad. The diagnosis depends on histology and immunohistochemistry. Complete resection plus postoperative radiotherapy is the best treatment

关 键 词：淋巴上皮癌 涎腺 临床病理 

分 类 号：R739.87[医药卫生—肿瘤]