凋亡抑制蛋白livin在人非小细胞肺癌中的表达以及和survivin表达的关系  

Expression and correlation of livin and survivin proteins in non-small cell lung cancer

作　　者：刘益飞[1] 施公胜[1] 刘俊华[1] 姚登福[1] 章建国[1] 黄华[1] 

机构地区：[1]南通大学附属医院病理科,江苏南通226001

出　　处：《现代肿瘤医学》2010年第2期294-296,共3页Journal of Modern Oncology

基　　金：江苏省卫生厅资助项目(编号:H200728)

摘　　要：目的:探讨非小细胞肺癌(NSCLC)组织中凋亡抑制蛋白livin表达及其与各临床病理因素的关系,以及和凋亡抑制蛋白survivin表达的相关性。方法:采用免疫组织化学法检测100例NSCLC患者的病变肺组织(肺癌组)以及10例正常或肺良性疾病患者肺组织(对照组)livin蛋白和survivin蛋白的表达水平,并分析2者与肺癌的组织类型、分化程度、淋巴结转移之间的关系,以及2种蛋白表达的相关性。结果:100例NSCLC组织中livin表达阳性率为68.0%、survivin为62.0%,而在正常和癌旁组未检出阳性结果;livin的表达与组织分化和淋巴结转移有关,组织分化差,淋巴结转移者livin表达率高(P<0.05).62例survivin阳性样本中有38例livin呈阳性。结论:livin和survivin蛋白在癌组织中表达上调,提示其可能在非小细胞肺癌发生发展中起促进作用。survivin和淋巴结转移的密切关系表明它的高表达可能反映患者较差的预后。livin基因可能成为非小细胞肺癌治疗的一个靶基因。Objective：To study the expression of livin, a novel inhibitor of apoptosis protein （IAP） family member,in non - small cell lung cancer （NSCLC） and to explore the relationship between livin expression and clinical parameters. Methods： The expression of livin and surrvivin protein was detected by immunohistochemistry method in lung tissues of 100 patients with NSCLC and 10 normal control or patients with benign lung diseases. Results： Livin was expressed in 68 out of 100 cases of non small cell lung cancer （68%） surviving was expressed in 62 out of 100 cases （62%）. No livin and survivin expression was detected in para -cancerous or benign tissues. There was a relationship between the exprssion of livin and degrees of differentiation and metastases （ P 〈 0.05 ） Livin and survivin were present in 38 of 100 carainoma cases simuhenuously. Conclusion： Up regulated expression of livin and survivin may play an important role in non - small cell lung cancer （NSCLC） development. The relationship between survivin and lymph node metastasis indicates that higher survivin expression may predict poor prognosis.

关 键 词：LIVIN SURVIVIN 免疫组化 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]