人端粒酶催化亚单位和c-myc蛋白在胃癌及癌前病变中的表达及意义  

Expression and significance of hTERT protein and c-myc protein in human gastric cancer and precancerous lesion

作　　者：滕小春[1] 刘海峰[2] 王国安[2] 

机构地区：[1]重钢总医院老年科,重庆400080 [2]北京武警总医院消化内科,北京100039

出　　处：《现代肿瘤医学》2010年第2期327-329,共3页Journal of Modern Oncology

摘　　要：目的:探讨人端粒酶催化亚单位(human telomerase catalytic subunit,hTERT)和c-myc蛋白在胃癌和胃癌前病变中的表达及意义。方法:应用免疫组织化学技术检测71例慢性胃炎和胃癌中hTERT和c-myc蛋白的表达,其中慢性胃炎伴萎缩者18例,伴肠化生者16例,伴中、重度不典型增生者16例,胃癌21例。结果:hTERT和c-myc蛋白的表达率在胃癌组织中均高于不典型增生、肠化生和萎缩性胃炎组织(P<0.05);在不典型增生组织中均显著高于肠化生、萎缩性胃炎组织(P<0.05);在肠化生组织中均显著高于萎缩性胃炎组织(P<0.05)。hTERT蛋白表达率在c-myc蛋白阳性患者中显著高于c-myc蛋白阴性患者(P<0.01)。结论:hTERT与c-myc蛋白在胃癌发生发展过程中,均可能发挥重要作用,对胃癌的发生、发展起促进作用,c-myc表达增加可能是胃黏膜上皮细胞端粒酶激活的重要机制之一。Objective：To study the expression and significance of hTERT protein and c - myc protein in human gastric mucous membrance lesions and precancerous lesion. Methods： The expression of hTERT protein and c - myc protein in 50 chronic gastritis and 21 gastric carcinoma was studied by using immunohistochemical method. Results： The positive expression of hTERT protein and c - myc protein in human gastric carcinoma was significantly higher than in gastric dysplasia, intestinal metaplasia and chronic atrophic gastritis （ P 〈 0.05 ）. The positive expression of hTERT protein and c - myc protein in gastric dysplasia was significantly higher than in intestinal metaplasia and chronic atrophic gastritiS（ P 〈 0.05 ）. The positive expression of hTERT protein and c -myc in intestinal metaplasia was significantly higher than that in chronic atrophic gastritis（ P 〈 0.05 ）. The positive expression of hTERT protein in patients with positive expression of c - myc protein was significantly higher than that in those without positive expression of c -myc protein（P 〈 0.01 ）. Conclusion： Both c -myc expression and the activity of telomerase may play roles in gastric carcinoma by promoting pathogenesis and development of gastric carcinoma, and c - myc protein expression may play an important role in activing telomerase.

关 键 词：胃癌 人端粒酶催化亚单位 c—myc 

分 类 号：R735.2[医药卫生—肿瘤]