左乙拉西坦单药治疗成人癫60例临床研究  

Clinical Observation of Levetiracetam Monotherapy of Adult Patients with Epilepsy

作　　者：胡崇宇[1] 肖波[1] 李国良[1] 李蜀渝[1] 唐微婷[1] 易芳[1] 

机构地区：[1]中南大学湘雅医院神经内科,长沙410008

出　　处：《神经损伤与功能重建》2010年第1期27-29,共3页Neural Injury and Functional Reconstruction

基　　金：卫生部临床学科重点项目(卫规财函[2007]353)

摘　　要：目的:研究左乙拉西坦(LEV)单药治疗成人癫的临床疗效及副作用。方法:对60例成人癫患者进行LEV单药治疗的开放性自身对照研究,根据发作类型分为部分性发作组35例和全面性发作组25例,观察其疗效及副作用。结果:LEV单药治疗后癫发作完全控制率21.7%,有效率50%;部分性发作组完全控制率17.1%,有效率45.7%,全面性发作组完全控制率28%,有效率56%,2组间疗效比较差异无统计学意义。11例出现不良反应,包括嗜睡、头晕、食欲下降和兴奋激动,均可耐受。结论:LEV单药治疗成人各类型癫均有疗效,不良反应轻。Objective,To evaluate the efficacy and side effects of Levetiracetam （LEV） as a monotherapy in the treatment of adult patients with epilepsy. Methods： In this open self-controlled study, 60 adult patients with epilepsy had been treated with LEV for 5 to 12 months and the efficacy and side effects of LEV were assessed. Results： As for the all 60 cases, the total control rate （seizure free） was 21.7% and the effective rate （seizure frequency reduction≥50 %） was 50 %. As for the partial seizure group （n= 35） the total control rate was 17.1% and the effective rate was 45.7%; as for the generalized seizure group （n=25） the total control rate was 28% and the effective rate was 56 %. There was no significant difference between the two groups. Eleven patients had tolerable side effects including sleepiness, dizziness, excitement and loss of appetite. Conclusion： LEV monotherepy was an effective treatment for adult patients with different types of epilepsy.

关 键 词：癫痫 抗癫痫药物 左乙拉西坦 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学]