血清α-L-岩藻糖苷酶与甲胎蛋白和糖类抗原19-9在原发性肝癌诊断中的作用  

Serum α-L-fucosidase and alpha-fetoprotein and carbohydrate antigen 19-9 in the diagnosis of primary liver cancer.

作　　者：熊利华 陈春琴 张春峰 方叶青 

机构地区：[1]嘉兴市海盐中医院检验科,浙江嘉兴314300 [2]杭州市桐庐县第二人民医院检验科,浙江杭州311500

出　　处：《临床和实验医学杂志》2010年第4期263-264,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血清α-L-岩藻糖苷酶(AFU)、甲胎蛋白(AFP)和糖类抗原19-9(CA19-9)在原发性肝癌(PHC)诊断中的作用。方法分别测定PHC患者48例、肝硬化患者28例、乙型肝炎患者74例、其他肿瘤患者38例和正常人136例AFU、AFP和CA19-9含量。结果AFU、AFP和CA19-9在PHC患者中的敏感性分别为79.2%、68.6%和62.5%,在AFP阴性的PHC患者中,AFU、CA19-9的敏感性分别为62.5%和75.0%,3项联合检测诊断PHC的敏感性为87.5%。结论AFU、AFP、CA19-9 3项联合检测对提高原发性肝癌的诊断率有十分重要意义。Objective To study the significance of serum alpha - L -fucosidase（AFU） ,fetoprotein（AFP） and CA19 -9 in the diagnosis of primary hepatic carcinoma（PHC）. Methods The activities of serum AFU and AFP were measured in 48 cases of PHC,28 cases of liver cirrhosis ,74 cases of hepatitis, 38 caese of others tumour and 136 Normal controls average person. Results The activity in patients with PHC were signif- icantly higher than any other groups. The diagnostic sensitivities of serm AFU ,AFP and CA19 -9 in patients with PHC were 79.2% ,68.6% and 62.5% ;respectively. Get in the AFP negative gender inside,AFU is 62.5% and CA19 -9 is 75.0%. and the combined diagnostic sensitivity of AFU,AFP and CA19 -9 reached the level of 87.5%. Conclusion It＇s to elevate their sensitivity and specificity in combination with AFU,AFP and CA19 -9 to diagnose about primary, hepatic carcinoma. Their expressions what important function an act of diagnosing the primary hepatic carcinoma（PHC）.

关 键 词：α—L-岩藻糖苷酶 原发性肝癌 甲胎蛋白 糖抗原19—9 

分 类 号：R735.7[医药卫生—肿瘤]