脑卒中后运动神经网络重组的横向功能磁共振研究  

The plasticity of motor neural net After stroke:a cross-sectional functional MRI study

作　　者：刘圣华[1] 储成凤[2] 杨明[1] 刘斌[1] 魏松宇[1] 

机构地区：[1]东南大学附属中大医院放射科 [2]江苏省南京市东南大学附属中大医院放射科,210009

出　　处：《中国CT和MRI杂志》2010年第1期1-4,共4页Chinese Journal of CT and MRI

基　　金：东南大学科技基金资助项目(KJ0790300);部分受973项目资助(2007CD512303)

摘　　要：目的利用功能磁共振成像研究运动功能不同程度恢复卒中患者被动运动任务时大脑的激活差异。方法对20例卒中患者分别行双侧腕关节被动运动的功能MRI扫描,采用SPM2软件进行数据分析和脑功能区定位。结果不同恢复程度的卒中患者患肢腕关节被动运动激活脑区不同:恢复较好者,以对侧感觉运动区(SMC)、同侧小脑、双侧辅助运动区(SMA)激活显著;恢复不好者,远隔部位激活较显著。患者健肢激活脑区及面积均未见明显差异。结论对侧SMC及SMA对运动功能恢复起至关重要的作用;健侧大脑半球的代偿作用对患肢运动功能的恢复影响较大。Objective To study the similarities and differences of hand motor area in the patient with cerebral infaction during passive wrist movement with functional magnetic resonance imaging. Methods Twenty stroke patients were scanned while they were performing the passive movement tasks with their right and left wrist and SPM2 was adopted to process the fMRI data and to localize the functional areas. Results The area activated in different degree of recorvey were differenf°for the subject with better recovery, contralateral sensorimotor cortex, ipsilateral cerebellum and bilateral SMA were activated; the patients with relatively bad recovery have significantly activation in some distant area. Conclusion Contralateral sensorimotor cortex and bilateral supplementary area play an important role in the recovery of motor function.

关 键 词：卒中康复 功能磁共振 运动系统 神经重塑 

分 类 号：R743[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]