抽动秽语综合征患者血清自身抗体与可溶性白介素-6受体表达增高  

Increased expression of autoantibody protein and soluble IL-6 receptor in serum of patients with Tourette's syndrome

作　　者：程宇航[1] 郑毅[1] 王丽芳[1] 刘瑞玫[1] 高扬[2] 

机构地区：[1]首都医科大学附属北京安定医院临床检验与实验中心,北京100088 [2]中国医学科学院北京协和医学院基础医学研究所免疫室,北京100005

出　　处：《基础医学与临床》2010年第2期113-116,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(30540069)

摘　　要：目的探讨抽动秽语综合征(TS)病程中自身免疫损伤相关机制。方法用ELISA法检测TS患者血清中抗脑抗体(ABAb)、抗核抗体(ANAb)、可溶性白介素-6受体(sIL-6R)及可溶性gp130(sgp130)的含量,用胶乳增强免疫比浊法检测抗链球菌溶血素O抗体(ASO)水平。结果TS组血清sIL-6R和sgp130含量显著高于对照组[(44.1±15.8)ng/mLvs(30.3±9.0)ng/mL和(69.0±24.6)ng/mLvs(47.3±14.1)ng/mL,P<0.01];血清ABAb和ANAb检出率显著高于对照组(66%vs4%和53%vs25%,P<0.01),并且ASO增高的比例高于对照组(P<0.01);TS组ABAb水平与sgp130呈负相关(r=0.375,P<0.05)。结论TS患者依赖IL-6信号传导的生理功能上调和反馈抑制的网络机制启动;自身免疫相关的损伤机制均可能参与了疾病发生发展的病理生理过程。Objective To explore the mechanism of immunologic injury in patients with Tourette＇s syndrome（TS）. Methods The serum level of anti-brain antibody （ABAb）, antinuclear antibody （ANAb）, soluble IL-6 receptor （sIL-6R） and soluble gp130 （sgp130） in patients with ＇IS were analyzed by commercially available ELISA kits, and the titer of anti-streptolysin O（ASO） in TS and in control was examined with latex enhanced immunoturbidimetry. Results The level of sIL-6R and sgp130 was significantly elevated in TS compared with control group[ （44. 1± 15.8） ng/mL vs （30. 3 ±9. 0） ng/mL and （69. 0 ±24. 6）ng/mL vs （47. 3 ± 14. 1 ） ng/mL,P 〈0. 01 respectively]. ASO titer（250 IU/mL） was found higher in TS than that in control（P 〈0. 01 ）. The positive rates of anti-brain antibody and antinuclear antibody in TS were higher than that in control group （66% vs 4% and 53% vs 25%, P 〈0. 01 respectively）. The level of ABAb negatively correlated with sgpl30 concentration（ r =0. 375, P 〈0. 05 ）. Conclusion IL-6 signal transduction might be involved in Tourette＇s syndrome to lead the function enhancement and start cascade of feedback inhibition, because of elevated levels of sIL-6R, sgp130, ANAb and ABAb in serum. Autoimmune-related injuries may potentially explain the pathogenesis of the disease.

关 键 词：抽动秽语综合征 自身抗体 抗链“O” 可溶性白细胞介素6受体 可溶性GP130 

分 类 号：R749.94[医药卫生—神经病学与精神病学]