277例精神分裂症住院患者肝脏B超检查结果分析  

Result analysis of liver B-ultrasound examination in 277 schizophrenia inpatients

作　　者：杨文[1] 徐成惠[1] 刘光美[1] 

机构地区：[1]四川省攀枝花市第三人民医院,617061

出　　处：《检验医学与临床》2010年第3期201-202,204,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨长期服用抗精神病药(APS)的精神分裂症住院患者的肝脏B超检查异常情况。方法采用日立超声诊断仪,对持续服用APS≥2年的精神分裂症住院患者共277例进行肝脏B超分析,并与健康对照组比较。按药物使用情况将患者分为经典APS组、非经典APS组及联合用药组。结果长期服用APS治疗的慢性精神分裂症住院患者肝脏B超检查的结果异常109例,阳性率39.4%。精神分裂症患者肝脏B超检查阳性率及脂肪肝发生率与健康对照组比较差异有统计学意义(P<0.01);精神分裂症患者肝脏B超检查阳性结果中,单纯性脂肪肝及肝弥漫性改变与健康对照组比较差异有统计学意义(P<0.05);其中联合用药组肝脏B超检查阳性率及脂肪肝发生率与经典及非经典APS组比较差异有统计学意义(P<0.05)。结论长期服用APS易导致精神分裂症患者不同程度的肝脏损伤,尤以联合用药组肝脏损伤最为显著,应定期检查,及时调整用药、及时防治肝损伤。Objective To discuss the abnormal conditions of live B-ultrasound examination in schizophrenia inpatients with taking antipsychotics（APS） for long time. Methods By using the Hitachi Supersonic diagnostic equipment, the study group had 277 inpatients with APS for at least 2 years, the control group had 120 healthy people. The examination results were compared between the two groups. According to using APS conditions, the patients were divided into the classic APS group,the non-classic APS group and the union medication group. Results The B-ultra sound examination results showed 109 abnormal cases in the patients using APS for long-term with the positive rate of 39.4%. The positive rate and the incidence of fatty liver in the schizophrenia inpatients had statistical difference compared with the control group（P〈0.05）. In the positive results of B-ultrasound examination for the schizophrenia inpatients, simple fatty liver and liver diffused change had statistical difference compared with the control group（P〈 0.05）. The positive rate and fatty live incidence in the union medication group had statistical difference compared with the classic and non classic APS groups（P〈0. 05）. Conclusion Long term taking APS easily cause the varied degree of live damage in the schizophrenia inpatients,and union medication caused liver damage is most remarkable especially. It should be essential to conduct periodic examination, timely adjustment of medication, prompt prevention and treatment.

关 键 词：精神分裂症 抗精神病药 B超 阳性率 

分 类 号：R749.29[医药卫生—神经病学与精神病学]