老年反流性食管炎食管外表现治疗的研究  

Therapy of extraesophageal manifestation of reflux esophagitis in the elderly

作　　者：赵莉[1] 许乐[1] 刘方旭[1] 石蕾[1] 张雷[2] 杨鹤[3] 

机构地区：[1]卫生部北京医院消化科,北京100730 [2]卫生部北京医院耳鼻喉科,北京100730 [3]卫生部北京医院呼吸科,北京100730

出　　处：《中国医刊》2010年第2期36-38,共3页Chinese Journal of Medicine

摘　　要：目的探讨老年反流性食管炎伴食管外表现患者质子泵抑制剂(PPI)的治疗效果。方法研究对象均经胃镜检查证实为反流性食管炎,具有胃灼热、反酸等胃食管反流症状和食管外症状(咳嗽、喉炎、哮喘),且24小时食管pH监测阳性。依据患者的年龄分为老年组(≥60岁)及非老年组(<60岁)。老年组36例,对照组30例。所有患者均给予质子泵抑制剂埃索美拉唑20mg,每日2次,疗程8周,治疗后复查胃镜、24小时食管pH监测及症状改善情况。结果治疗后老年组与非老年组的胃镜检查、酸暴露及症状均有显著改善,且两组比较差别无显著性意义。结论 PPI治疗老年反流性食管炎伴食管外表现患者的疗效较好,与青年患者类似。ObjectiveThe aim of this prospective study was to investigate the therapeutic effect of proton pump inhibitor（PPI） in the elderly with extraesophageal reflux disorders of reflux esophagitis （RE）. Methods We investigated RE patients in Beijing hospital in a same time period. These patients were diagnosed RE on endoscopy. The elderly group 36 patients, and the control group 30 patients, extraesophageal reflux disorders symptoms and the reflux symptoms were evaluated by questionnaire. All patients underwent 24-h esophageal pH monitoring, symptom score evaluation, and 24-h esophageal pH monitoring is positive. All patients were treated with esomeprazole, 20mg twice daily for 8 weeks. Results The elderly group and the control group improve significantly on esophagitis, 24h esophageal pH monitoring and symptoms after treatment, furthermore there were no significant difference between them. Conclusions The effect of the same dose PPI is similar between the elderly and the younger adult.

关 键 词：老年 食管外表现 质子泵抑制剂 

分 类 号：R571[医药卫生—消化系统]