D2-40检测LVD与胃癌临床病理的关系  

Correlations of lymphatic vessel density and clinicopathologic parameters in gastric carcinoma detected by D2-40

作　　者：吴勇军[1,2] 李筝[2] 张漾[2] 赵毅[2] 伍镇江[2] 苏琦[1] 

机构地区：[1]南华大学肿瘤研究所,衡阳421001 [2]湘潭市第一人民医院／南华大学湘潭临床学院

出　　处：《中国临床实用医学》2010年第1期5-7,共3页China Clinical Practical Medicine

基　　金：湖南省科技厅科技计划（项目编号：2008SK3010）;湘潭市科技局科技计划项目（项目编号：SF20081003）;湖南省重点学科建设项目基金（项目编号：2006-180）

摘　　要：目的探讨胃癌组织淋巴管密度（1ymphotic vessel density，LVD）与临床病理的关系。方法免疫组织化学检测胃癌组织D2-40的表达，并计数LVD。结果52例胃癌总LVD均值为18．19．7，肿瘤内及边缘分别为16．449．62、19．9010．13，明显高于正常胃组织6．583．87（P〈0．05）。低分化胃癌边缘23．211．6显著高于高中分化胃癌15．75．9（P〈0．05）。淋巴结转移者21．910．8较无淋巴结转移者14．95．9显著升高（P〈0．05）。胃癌边缘LVD与浸润深度、临床分期及肿瘤内与边缘无显著性差异。结论胃癌肿瘤内与边缘LVD显著高于正常组织，与分化程度及淋巴结转移相关，提示LVD增加可能与胃癌的侵袭转移有关。Objective To investigate the correlations of lymphatic vessel density （LVD）and clinicopathologic parameters in gastric carcinoma. Methods The expression of monoclonal antibody D240 was detected by immunohistochemistry and to count LVD in gastric carcinoma. Results LVD mean was 18.19. 7 in 52 cases of gastric carcinoma. 19. 9010. 13 and 16. 449. 62 in the peritumoural and intratumoural area,respectively, were significantly higher than 6. 583.87 in normal gastric tissue （P 〈 0. 05 ）. 23. 211.6 of poorly-differentiated was significantly higher than 15.75. 9 of differentiated in peritumoural area（P 〈0. 05）. 21. 910. 8 in lymphatic metastasis was obviously higher than 14. 95.9 in non-metastasis（ P 〈 0. 05 ）. LVD of edges in gastric carcinoma was not related with invasion depth and clinical stage （ P 〉 0. 05 ） o There no was significant difference between LVD in peritumoral and intratumoural areas（ P 〉 0.05 ）. Conclusion LVD in the peritumoural and intratumoural area were significantly higher than in normal gastric tissue, and closely associated with differentiation degree and mestasis. It is suggest that LVD increasing may be concerned with metastasis in gastric carcinoma.

关 键 词：胃癌 D2-40 淋巴管密度 转移 

分 类 号：R735.2[医药卫生—肿瘤]