抗核抗体和T细胞免疫异常在口腔扁平苔藓和复发性口腔溃疡及慢性盘状红斑狼疮患者中的比例  

Frequencies of presence of serum antinuclear antibody and T-lymphocyte subsets changes in oral lichen planus,recurrent aphthous ulcerations and discoid lupus erythematosus patients

作　　者：赵民[1] 吕红[1] 

机构地区：[1]山东大学附属省立医院口腔内科,山东济南250012

出　　处：《国际口腔医学杂志》2010年第1期14-16,共3页International Journal of Stomatology

基　　金：山东省优秀中青年科学家科研奖励基金资助项目(20-08BSB14024)

摘　　要：目的比较口腔扁平苔藓(OLP)、复发性口腔溃疡(ROU)和慢性盘状红斑狼疮(DLE)患者自身抗核抗体(ANA)和T细胞免疫异常的差别,为探讨其发病机制奠定基础。方法流式细胞仪检测口腔扁平苔藓、复发性口腔溃疡和慢性盘状红斑狼疮患者外周血血清T细胞亚群,间接免疫荧光法检测ANA,比较ANA和T细胞免疫异常的比例。结果口腔扁平苔藓、复发性口腔溃疡和慢性盘状红斑狼疮3组患者间ANA的阳性率,慢性盘状红斑狼疮组为29.0%(9/31),口腔扁平苔藓组为6.25%(5/80),复发性口腔溃疡组为1.7%(2/115)。CD3+细胞在3组中均以降低占最大比例,其中复发性口腔溃疡组为52.2%(60/115),慢性盘状红斑狼疮组为51.6%(16/31),口腔扁平苔藓组为50%(40/80)。CD4+细胞在口腔扁平苔藓组以正常占最大比例,为75%(60/80);而在慢性盘状红斑狼疮组却以降低占最大比例,为54.8%(17/31)。结论3组患者间的ANA阳性率和T细胞亚群检测结果差异均有统计学意义。Objective To study frequencies of presence of serum antinuclear antibody（ANA） and T-lymphocyte subsets changes in oral lichen planus（OLP）,recurrent oral ulcerations（ROU） and discoid lupus erythematosus（DLE） patients.Methods In this study,the serum levels of ANA were measured in a group of 80 Chinese OLP patients,115 ROU patients,31 DLE patients and to detect the peripheral blood T-lymphocyte subsets by flow cytometer.Results The frequencies of presence of serum ANA and T-lymphocyte subsets changes were different among three groups.The frequencies of presence of serum ANA in DLE group,OLP group,ROU group were 29.0%（9/31）,6.25%（5/80） and 1.7%（2/115） respectively.The proportion of reduced CD3＋ T-lymphocytes subsets was 51.6%（DLE group）,50%（OLP group） and 52.2%（ROU group） respectively.In OLP group,most patients（75%） had normal CD4＋ T-lymphocytes subsets.And in DLE group the proportion of reduced CD4＋ T-lymphocytes subsets was 54.8%（17/31）.Conclusion There are significantly difference in T-lymphocyte subsets changes and frequencies of presence of serum ANA among DLE group,OLP group and RAU group.

关 键 词：口腔黏膜病 抗核抗体 细胞免疫 

分 类 号：R781.5[医药卫生—口腔医学]