解郁1号对SS调衡HPA轴功能的干预研究  

Study on Intervention of Jieyu Yihao on SS' regulating function of HPA axis

作　　者：武丽[1] 张丽萍[1] 夏猛[1] 肖宁[1] 

机构地区：[1]广西中医学院,广西南宁市明秀东路179号530001

出　　处：《世界中医药》2010年第1期62-63,共2页World Chinese Medicine

基　　金：国家自然科学基金项目(30660231)

摘　　要：目的:探讨以调理脾胃气机法组成的中药复方解郁1号对SS调衡HPA轴功能的干预机制。方法:60只SD大鼠随机分为正常对照组、模型对照组、阿米替林组及解郁1号组,应用孤养加慢性轻度不可预见性应激方法复制大鼠抑郁症模型,采用放射免疫法测定血浆促肾上腺皮质激素释放激素(CRH)、生长抑素(SS)、皮质醇(CORT)的含量,分析SS、CRH、CORT之间的相关性。结果:SS与CRH之间的相关系数为r=-0.5094,P=0.1972,t=1.4501,结果表明SS与CRH呈显著负相关;SS与CORT之间的相关系数为r=0.010,P=0.9613,t=0.0244,结果表明SS与CORT之间无明显相关性。结论:SS可能通过抑制CRH的释放,达到对HPA轴的调衡作用。而解郁1号则可能通过对SS调衡HPA轴功能的干预,发挥其抗抑郁效应。Objective：To explore the intervention mechanism of Jieyu Yihao, a Chinese compound for promotion of qi in spleen and stomach, on SS＇regulating function of HPA axis. Methods： Sixty SD rats, randomly allocated to normal control group, model control group, amitriptyline group, and Jieyu Yihao group, were raised lonely, and given chronic, mild and unforeseeable stress. To measure CRH, SS, CORT by radio-immunity methods, and carry out correlation analysis. Results：SS was negatively correlated to CRH （r = -0. 5094, P = 0. 1972, t = 1. 4501 ）, and not significantly correlated to CORT （ r = 0. 010, P = 0.9613, t = 0. 0244 ）. Conclusion： By inhibiting the release of CRH, SS regulate HPA axis. Jieyu Yihao can intervene SS＇ regulating function on HPA axis which may explain its mechanism for anti-depression.

关 键 词：抑郁症/中医药疗法 解郁1号 SS HPA轴 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R442.8[医药卫生—临床医学]