尿酸对认知功能的影响  

Effect of Serum Uric Acid on Cognitive Function

作　　者：王晓君[1] 罗蔚锋[1] 刘春风[1] 

机构地区：[1]苏州大学附属第二医院神经内科

出　　处：《国际老年医学杂志》2010年第1期16-20,共5页International Journal of Geriatrics

摘　　要：阿尔茨海默病和帕金森病足老年人常见的神经退行性疾病。认知功能障碍是阿尔茨海默病的主要临床表现,帕金森病在发展过程中,尤其到疾病晚期,可合并有痴呆表现,称帕金森病痴呆。不同的调查研究显示,帕金森病患者中有17%～57%会伴发认知功能障碍。研究影响认知功能的相关因素对于防治阿尔茨海默病,提高帕金森病患者的生活质量具有重要的意义。近年来发现,血尿酸水平与认知功能密切相关。Alzheimer＇s disease（AD） and Parkinson＇s disease（PD） are common neurodegenerative diseases in older people. Cognitive imparement is a major clinical manifestations of AD. In the development of PD（ especially in advanced stage PD） it may be cornbined with dementia,which is called Parkinsong disease dementia. Based on the findings of various studies, 17% -57% of the patients with PD are combined with cognitive impairment. Researching the relevant factors of cognitive function is very important to prevent AD and may improve the quality of life in patients with PD. Based on the results discovered in recent years, serum uric acid levels are thought to be closely related to cognitive function.

关 键 词：痴呆 认知功能障碍 动脉粥样硬化 氧化应激 尿酸 

分 类 号：R749.1[医药卫生—神经病学与精神病学]