整合素α6、β1亚基在人脑星形细胞瘤的表达特征  

Expression patterns of integrin α6、β1 subunit in the human brain astrocytoma

作　　者：冯兵[1] 林志雄[2] 常文海[1] 张俊杰[1] 姬馨彤[1] 张五中[1] 

机构地区：[1]河南省焦作市人民医院神经外科,454002 [2]福建医科大学附一医院神经外科

出　　处：《中国临床实用医学》2010年第2期32-34,共3页China Clinical Practical Medicine

摘　　要：目的探索整合素α6、β1亚基在人脑星形细胞瘤中的表达情况。方法采用免疫组织化学方法SP检测42例人脑星形细胞瘤标本中整合素α6、β1亚基的表达情况。结果在人脑星形细胞瘤标本中，整合素各亚基阳性染色主要定位于肿瘤细胞和部分血管内皮细胞，整合素α6亚基的阳性染色强度随着肿瘤级别的增高而显著降低，整合素β1亚基的阳性染色强度随着肿瘤级别的增高而显著增高，高级别组与低级别组之间的阳性表达有显著性差异（P〈0．05）。结论整合素α6、β1亚基的表达强度参与人脑星形细胞瘤恶性行为的调控。Objective To explore expression patterns of integrin α6、β1 subunit in the human brain astrocytoma. Methods To examine the expression of integrin α6、β1 subunit in 42 cases of human brain astrocytoma specimens by immunohistochemistry. Results In the human brain astrocytoma specimens, integrin subunit positive staining was localized mainly in the glioma cells and some in blood vessel endothelial cells. The expression of integrin α6 subunit with histological grade were significantly decreased. The expression of integrin 1 subunit with histological grade were significantly increased. Low-level and high-level group showed a significant difference in expression （P 〈 0. 05）. Conclusion The expression of integrin α6、β1 subunit in the human brain astrocytoma control its malignant behavior.

关 键 词：星形细胞瘤 整合素 免疫组化 

分 类 号：R739.4[医药卫生—肿瘤]