嗜血细胞综合征患儿外周血CD_4^+CD_(25)^+调节性T细胞变化及临床意义  

Changes and clinical significances of CD_4^+CD_(25)^+ regulatory T cells in peripheral blood in children with hemophagocytic syndrome

作　　者：和迎春[1] 张群智[1] 宋建新[2] 李雪梅[1] 

机构地区：[1]大理学院附属医院检验科,云南大理671000 [2]云南省临床检验中心,云南昆明650032

出　　处：《中国微生态学杂志》2010年第2期152-153,157,共3页Chinese Journal of Microecology

摘　　要：目的观察嗜血细胞综合征(hemophagocytic syndrome,HPS)患儿外周血中调节性T细胞(RegulatoryTcells,Treg细胞)的变化,探讨其在HPS发病中的作用及临床意义。方法应用流式细胞仪检测17例初诊HPS患者(初诊组)、11例经诱导治疗后临床缓解者(缓解组)及20例健康人群(对照组)外周血中CD4+CD25+调节性T细胞。结果与对照组相比较,HPS患者初诊组及缓解组外周血CD4+CD25+调节性T细胞均升高(P<0.05)。与初诊组相比较,缓解组CD4+CD25+Treg细胞降低(P<0.05),但仍高于正常对照组(P<0.05)。结论CD4+CD25+Treg细胞增多可能是HPS患者免疫功能受抑的重要原因之一,其变化对于HPS的预后判断有一定的意义。Objective To observe the changes of CD4^＋ CD25^＋ regulatory T cells（Treg cells） in peripheral blood in children with hemophagocytic syndrome（HPS） in order to reveal the role of Treg cells in the pathogenesis of HPS and evaluate its clinical significance.Method The flow cytometry was used to determine the proportion of CD4^＋ CD25^＋Treg cells in the peripheral blood of 17 patients with HPS who were newly diagnosed（newly diagnosed group）,11 patients with AML who achieved complete remission（CR group） and 20 normal healthy people（control group）.Result Compared with that of control group,the proportion of CD4^＋ CD25^＋ Treg cells in newly diagnosed group and in CR group were significantly increased（P〈0.05）.The proportion of CD4^＋ CD25^＋ Treg cells in CR group were lower than that in newly diagnosed group（P〈0.05）,but were still higher than that in control group（P〈0.05）.Conclusion The increase of CD4^＋ CD25^＋ regulatory T cells is likely to be one of the important factors that result in immunologic suppression in patients with hemophagocytic syndrome,and which is of significances in prognosis of HPS.

关 键 词：CD4^+CD25^+调节性T细胞 嗜血细胞综合征 

分 类 号：R577.2[医药卫生—消化系统]