Practical and Efficient Acylation and Tosylation of Sterically Hindered Alcohols Catalyzed with 1-Methylimidazole  

作　　者：WU Qin-pei LIU Hua LIU Hai-xia CHEN Xi WANG Hao ZHANG Qing-shan LI Yun-zheng 

机构地区：[1]Department of Applied Chemistry [2]School of Life Science, Beijing Institute of Technology, Beijing 100081, P. R. China

出　　处：《Chemical Research in Chinese Universities》2010年第1期55-59,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.30340070)

摘　　要：Acylation of sterically hindered alcohols is frequently encountered in synthetic chemistry. An efficient and mild procedure for tosylation and esterification of sterically hindered hydroxyl groups with p-TsCl, Ac20 and Bz20 in the presence of l-methylimidazole is described. It was observed that auxiliary base, triethylamine, accelerates the acylation reaction.Acylation of sterically hindered alcohols is frequently encountered in synthetic chemistry. An efficient and mild procedure for tosylation and esterification of sterically hindered hydroxyl groups with p-TsCl, Ac20 and Bz20 in the presence of l-methylimidazole is described. It was observed that auxiliary base, triethylamine, accelerates the acylation reaction.

关 键 词：ESTERIFICATION IMIDAZOLE Nucleophilic catalysis ORGANOCATALYSIS 

分 类 号：TQ225.241[化学工程—有机化工] TU528.042[建筑科学—建筑技术科学]