常规加调强适形推量放疗联合化疗治疗术后胶质肉瘤  

Conventional radiotherapy followed by IMRT as a boost combined with chemotherapy treatment for gliosarcoma

作　　者：汪洋[1] 潘力[1] 盛晓芳[1] 高晶[1] 陈淑[1] 孙磊[1] 董伟[1] 戴嘉中[1] 

机构地区：[1]复旦大学附属华山医院脑病中心上海伽玛医院肿瘤放疗中心,上海200233

出　　处：《中国微侵袭神经外科杂志》2010年第1期4-6,共3页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的探讨胶质肉瘤术后常规加调强适形(IMRT)推量放疗联合化疗的疗效。方法回顾性分析7例胶质肉瘤术后应用常规加IMRT推量放疗联合化疗病人的治疗经验。放疗总剂量为60Gy,其中常规放疗40Gy,后程IMRT20Gy。均行化疗,其中采用替莫唑胺方案3例,司莫司汀加替尼泊苷方案4例。结果本组急性治疗反应均为1～2级,治疗后均出现局部进展,中位局部进展时间为放疗开始后12.0个月,平均进展时间为13.7个月。并发脑内播散和肺转移1例。中位生存时间18.0个月,平均生存时间20.5个月。结论术后常规加IMRT推量放疗联合化疗治疗胶质肉瘤,病人对治疗反应可以耐受,生存时间略长于文献报道。Objective To evaluate the effects of conventional radiotherapy followed by intensity-modulated radiotherapy （IMRT） for gliosarcoma （GS）. Methods The experience in 7 patients with GS treated by conventional radiotherapy followed by IMRT was analyzed retrospectively. The total radiotherapy dose was 60 Gy, including 40 Gy for conventional radiotherapy and 20 Gy for IMRT. All the patients received chemotherapy, 3 temozolomide chemotherapy and the other 4 combined chemotherapy with semustine plus teniposide. Results Grade Ⅰ-Ⅱ of acute treatment-related toxicity was found in all the patients, and local progression was also occurred in all the patients. The median local progression time was 12.0 months after the treatment initiation and the average time was 13.7 months. One patient suffered tumor dissemination in the brain and lung metastases simultaneously. The median survival time was 18.0 months and the average was 20.5 months. Conclusions The treatment-related toxicity with combined radiotherapy of postoperative conventional radiotherapy plus IMRT for GS can be toleranced, and the survival time of the patient is longer than that previously reported.

关 键 词：神经胶质肉瘤 放射疗法 适形 抗肿瘤联合化疗方案 综合疗法 

分 类 号：R739.4[医药卫生—肿瘤]