Moesin在人脑星形细胞瘤的表达及意义  

Expression and significance of Moesin in human astrocytomas

作　　者：伍明[1] 唐薇婷[1] 唐智[1] 成磊[1] 李学军[1] 袁贤瑞[1] 

机构地区：[1]中南大学湘雅医院神经外科,湖南长沙410008

出　　处：《中华神经外科疾病研究杂志》2010年第1期15-18,共4页Chinese Journal of Neurosurgical Disease Research

基　　金：湖南省科技厅资助项目(2009JT3049)

摘　　要：目的探讨膜结构伸展刺突蛋白(Moesin)在人脑星形细胞瘤中的表达及意义。方法应用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶连结法(SP法),检测56例人脑星形细胞瘤和10例正常脑组织中Moesin和磷酸化Moesin的表达,并结合临床随访资料分析表达水平与星形细胞瘤临床预后的相关性。结果Moesin的阳性表达率在人脑星形细胞瘤组96.4%(54/56)和正常脑组织对照组0%(0/10)之间有统计学差异(P<0.01)。Ⅲ～Ⅳ级星形细胞瘤Moesin的强阳性表达高于Ⅰ～Ⅱ级,两者相比有统计学差异(χ2=27.50,P<0.01),磷酸化Moesin的表达结果与Moesin的结果基本一致。Moesin强阳性表达组患者比弱阳性+阴性表达组患者的术后无瘤生存时间短,其差异有统计学意义(χ2=29.85,P=0.000)。结论Moesin的表达水平与人脑星形细胞瘤的恶性程度密切相关,Moesin的过度表达对星形细胞瘤发展和预后起重要作用,提示Moesin可以作为反映星形细胞瘤预后的一种有价值的分子标志物。Objective To investigate the expression and significance of membrane structure extending spike protein （Moesin） in human astrocytoma. Methods A total of 56 cases of astrocytomas and 10 cases of normal brain tissue were used to detect the expression of Moesin and Phospho-Moesin by immunohistochemical streptavidin- perosidase （SP） method. The data of follow-up were also used to analyze the relationship between the expression level and the clinical prognosis of astrocytoma. Results The positive expression rate of Moesin was %.4% （54/56） in the human astrocytoma group and 0% （0/10） in normal brain tissue of control group. There was significantly statistical difference （ P 〈 0. 01 ）. Strong positive expression of Moesin in grade Ⅰ - Ⅱastrocytomas was enhanced with the increase of pathological grade in comparison to grade Ⅲ- Ⅳ astrocytomas （ χ^2 =27.50, P 〈0. 01）. The expression results of Phospho-Moesin were basically the same to Moesin＇s. The postoperative disease-free survival time in the patients of strong Moesin-positive expression group was shorter than that in the patients of weak positive ＋ negative expression group, with significant difference （ χ^2 = 29.85, P=0.000）. Conclusion Moesin expression levels are closely related to the nkalignancy of the human astrocytoma. The over-expression of Moesin plays an important role in the development and prognosis of astrocytoma which suggests that Moesin may be a valuable prognostic molecular marker for astrocytomas.

关 键 词：星形细胞瘤 膜结构伸展刺突蛋白 预后 

分 类 号：R739.4[医药卫生—肿瘤]