3.0T MR动态增强扫描对正常胰腺及胰腺癌的定量分析  

Quantitative analysis of normal pancreas and pancreatic carcinoma with dynamic contrast-enhanced MR imaging on 3.0T system

作　　者：马霄虹[1] 赵心明[1] 欧阳汉[1] 张红梅[1] 周纯武[1] 

机构地区：[1]中国医学科学院北京协和医学院肿瘤医院影像诊断科,北京100021

出　　处：《中国医学影像技术》2010年第1期10-13,共4页Chinese Journal of Medical Imaging Technology

基　　金："十一五"国家科技及支撑课题(2007BAI05B05)

摘　　要：目的对正常胰腺和胰腺癌患者的3.0TMR快速三维动态增强扫描序列进行定量分析,探讨其对胰腺癌诊断的临床应用价值。方法对34例经病理证实的胰腺癌患者(胰腺癌组)及31例非胰腺疾病患者(对照组)行全胰腺LAVA九期动态增强序列扫描,将所得数据传至ADW4.2工作站处理,分别测量对照组胰腺的头、体、尾及胰腺癌组病变区域及非病变区域的30s强化率(SER30)、90s强化率(SER90)、阳性强化积分值(PEI)、达峰时间(TTP)、最大强化斜率(MSI),并进行t检验。结果对照组胰腺头、体、尾的SER30、SER90、PEI、TTP及MSI差异无统计学意义。胰腺癌组病变区与非病变区的SER30、PEI、TTP、MSI差异均有统计学意义。对照组任意区域与胰腺癌组非病变区域或病变区域的TTP差异有统计学意义。结论正常胰腺的不同部位间无灌注差异,胰腺癌病变区域与非病变区域的灌注差异可以反映癌组织浸润范围。胰腺癌非病变区域与正常胰腺间TTP的差异可能反映潜在病变的可能。Objective To quantify the perfusion parameters of normal pancreas and pancreatic carcinoma with three-dimension（3D）fast spoiled gradient echo dynamic contrast enhanced（DCE）MRI on 3.0T MR system,and to assess the value of 3D DCE-MRI in the diagnosis of pancreatic carcinoma.Methods Thirty-four patients with pathology verified pancreatic carcinoma and 31 control subjects with normal pancreas（without pancreatic diseases）underwent DCE-MRI with 3D LAVA sequence of ten phases.The data were processed on ADW 4.2 workstation.The perfusion parameters of the head,body and tail of normal pancreas,together with lesion and non-lesion area of pancreatic carcinoma were measured and statistically analyzed,including signal enhancement ratio at 30 s after injection（SER 30）,signal enhancement ratio at 90 s after injection（SER 90）,positive enhancement integral（PEI）,time to peak（TTP）and maximum slope of increase（MSI）.Results There was no significant perfusion difference among head,body or tail of normal pancreas（P 〉0.05）.The difference of SER 30,PEI,TTP and MSI between lesion and non-lesion region of carcinous pancreas was significant（P〈 0.05）.The TTP between normal pancreas and the non-lesion region of carcinous pancreas was significantly different（P 〈0.05）.Conclusion Normal pancreas has no regional perfusion difference.The data from DCE-MRI provide reliable information for the diagnosis of pancreatic cancer,and for the assessment of the invasion of pancreatic carcinoma.The difference in TTP between the normal pancreas and non-lesion region of carcinous pancreas suggest the existing of potential lesions.

关 键 词：胰腺 胰腺肿瘤 磁共振成像 

分 类 号：R735.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]