经导管肝动脉化疗栓塞治疗肝细胞癌前后磁共振灌注成像观察  

Magnetic resonance perfusion imaging before and after transcatheter arterial chemoembolization treatment of hepatocellular carcinoma

作　　者：卞读军[1] 肖恩华[1] 胡冬煦[1] 肖运平[1] 陈翔宇[1] 司徒卫军[1] 贺忠[1] 袁术文[1] 孙剑宁[1] 

机构地区：[1]中南大学湘雅二医院放射科,湖南长沙410011

出　　处：《中国医学影像技术》2010年第1期89-92,共4页Chinese Journal of Medical Imaging Technology

基　　金：十一五国家科技计划项目(2007BAI05B06);国家自然科学基金(30070235;30470508;30870695);湖南省自然科学基金重点项目(06JJ20081);湖南省自然科学基金项目(07JJ6040);长沙市科技计划重点项目(K071532-11)

摘　　要：目的观察肝细胞癌(HCC)患者经导管动脉化疗栓塞(TACE)治疗前后磁共振灌注加权成像(MRPWI)灌注值改变。方法对22例HCC患者在TACE术前和术后3～10天分别进行MRPWI,得出术前及术后平均强化时间(MTE)、负增强积分(NEI)、病灶达峰值时间(TTP)、最大信号下降斜率(MSD),比较TACE术前与术后上述各指标的差异。结果HCC瘤区时间信号曲线(TIC)TACE术前呈快速下降,TACE术后趋向平缓;MTE与TTP值术后较术前降低,NEI值术后较术前升高,差异均有统计学意义(P<0.05);MSD值术后较术前降低,但差异无统计学意义(P>0.05)。结论MRPWI能够敏感地观察到HCCTACE术前后的血流变化,可用于评价TACE疗效。Objective To observe the change of MR perfusion value in patients with hepatocellular carcinoma（HCC）before and after transcatheter arterial chemoembolization（TACE）.Methods A total of 22 patients with HCC underwent MR perfusion weighted imaging（MR PWI）before TACE and 3-10 days after TACE.The mean time to enhance（MTE）,negative enhancement integral（NEI）,time to peak（TTP）and maximum slope of decrease（MSD）before and after TACE were acquired and compared.Results The time intension curve（TIC）of HCC region was observed to descend rapidly before TACE,while descended slowly after TACE.The value of MTE and TTP after TACE were lower than those before TACE（P〈 0.05）,and the value of NEI after TACE was higher than that before TACE（P 〈0.05）.The value of MSD after TACE were lower than that before TACE,but no statistical significance was found（P 〉0.05）.Conclusion MR PWI is a very sensitive imaging technique that be used to monitor blood flow changes of HCC before and after TACE and evaluate efficacy of TACE.

关 键 词：磁共振成像 灌注成像 癌 肝细胞的 经导管动脉化疗栓塞 

分 类 号：R735.7[医药卫生—肿瘤] R445.2[医药卫生—临床医学]