p53和nm23在结直肠癌中的表达  

Expression of p53 and nm23 in colorectal adenocarcinoma

作　　者：宋枫[1] 高峰[1] 董亮[2] 张鑫[1] 赵勇[1] 

机构地区：[1]兰州军区兰州总医院干部病房外科,甘肃兰州730050 [2]兰州军区兰州总医院病理科,甘肃兰州730050

出　　处：《西北国防医学杂志》2010年第1期19-21,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：甘肃省自然科学基金资助项目(0803RJZA054)

摘　　要：目的:探讨p53、nm23在结直肠癌中的表达及意义。方法:用免疫组化法测定83例结直肠癌组织中p53、nm23的表达情况。结果:p53、nm23在结直肠癌中的表达强度与肿瘤的浸润深度、组织学分级、淋巴结转移、远处转移等有关(P<0.05),与病变部位、性别、年龄无关(P>0.05),p53和nm23的表达呈负相关。结论:p53、nm23在结直肠癌的发生、转移及预后中起重要作用,检测p53、nm23有助于评价及判断预后。Objective：To investigate the expressions of p53 and nm23 in colorectal adenocarcinoma and their clinical significance.Methods： The expression of p53 and nm23 was examined by immunohistochemical method in 83 cases of colorectal adenocarcinoma.Results：The expression intensities of p53 and nm23 were corrected with tumor infiltration degree,pathological grade,lymph node metastasis and distant metastasis（P0.05）,but not with the tumor position,sex and age（P0.05）.Conclusion： p53 and nm23 play an important role in the development and metastasis of colorectal adenocarcinoma.They are helpful in evaluating and predicting prognosis of colorectal adenocarcinoma.

关 键 词：结直肠癌 P53 NM23 免疫组化 

分 类 号：R735.35[医药卫生—肿瘤]