周围型肺癌的CT征象与E—cadherin表达的相关性研究  

Study on the Correlation of Spiral CT Features with Expression of E--cadherin in Peripheral Lung Cancer

作　　者：吕传剑[1] 万娅敏[2] 陈学军[3] 史大鹏[1] 

机构地区：[1]河南省人民医院放射科,河南郑州450003 [2]郑州大学第一附属医院放射科 [3]郑州大学第五附属医院放射科

出　　处：《实用放射学杂志》2010年第1期24-27,共4页Journal of Practical Radiology

摘　　要：目的探讨周围型肺癌CT征象与E钙黏附蛋白（E～cad）表达间的关系。方法本组58例周围型肺癌患者，均采用螺旋扫描。标本4um连续切片，采用免疫组织化学S--P法检测肿瘤组织E—cad的表达。实验数据经SPSS10．0统计软件包进行统计学处理。结果E—cad异常表达32例，细胞分化Ⅰ～Ⅱ级组和Ⅲ～Ⅳ级组阳性表达率分别为40．63％和73．08％，2组间比较差异具有统计学意义（P〈0．05）。肺癌E—cad的异常表达与肿瘤的大小、棘突征、胸膜侵犯、淋巴转移明显相关（P〈0．05）。而与毛刺征、血管集中征、空洞征、胸膜凹陷征、分叶征无关（P〉0．05）。结论E～cad异常表达在肺癌的发生、发展及CT表现中可能起重要作用。Objective To investigate the correlation of spiral CT features with expression of E--cadherin（E--cad） in peripheral lung cancer. Methods Spiral CT scans were performed in 58 patients with peripheral lung cancer confirmed by pathology. Expression of E--cad in 58 cases were detected with SP immunohistoehemical techniques. Spiral CT findings were compared with expression of E--cad. Results The abnormal expression of E--cad was showed in 32 cases（55.17%）. The positive rates of E--cad expression were 40.63 % in Ⅰ--Ⅱ cell differentiation group and 73.08 % in Ⅲ--Ⅳ cell differentiation group,and the difference was significant（ P 〈0.05）. The abnormal expression of E--cad was associated with the CT features, such as lymph node metastasis, pleural invasion and the size of tumor（P〈0.05） ,but not the cavity sign, spicular sign and vessel convergence sign （P〉0.05）. Conclusion E--cad gene over expression may play an important role in the pathogenesis and CT appearances of lung cancer.

关 键 词：肺 肺癌 体层摄影术 X线计算机 E钙黏附蛋白 

分 类 号：R734.2[医药卫生—肿瘤] R719.8[医药卫生—临床医学]