生物催化法合成R-扁桃酸的研究进展  

Review on biocatalytic synthesis of R-mandelic acid

作　　者：陈艳[1] 薛亚平[1] 柳志强[1] 郑裕国[1] 

机构地区：[1]浙江工业大学生物工程研究所,浙江杭州310014

出　　处：《精细与专用化学品》2010年第2期55-60,共6页Fine and Specialty Chemicals

基　　金：国家863资助项目(No.2009AA02Z203)

摘　　要：R-扁桃酸作为一种重要的手性药物中间体和手性拆分试剂,在国内外得到广泛的应用。对于生物催化合成R-扁桃酸的研究已有不少,主要有微生物氧化还原酶、脂肪酶、腈水解酶3种不同途径生物催化合成R-扁桃酸。本文对R-扁桃酸的生物催化法合成进行了综述。R-Mandelic acid is an important medicinal intermediate for the production of pharmaceuticals and is also used as a chiral resolving agent. Many biocatalysts including oxidoreductases, lipase and nitrilase were developed to synthesize R-mandelic acid. In this work, a comprehensive review of the biocatalytic methods to produce R-mandelic acid has been shown.

关 键 词：生物催化 R-扁桃酸 氧化还原酶 脂肪酶 腈水解酶 

分 类 号：TQ463.2[化学工程—制药化工]