小儿急性白血病血清NO_2/NO_3和cGMP的变化  

CHANGE OF SERUM NITRIC OXIDE IN CHILDREN WITH ACUTE LEUKEMIA

作　　者：陈珊[1] 陈达光[1] 林娟[1] 张洪[2] 

机构地区：[1]福建医科大学附属协和医院儿科,350001 [2]同济医科大学附属协和医院

出　　处：《中国小儿血液》1998年第6期257-259,共3页China Child Blood

摘　　要：研究小儿性白血病血清NO_2／NO_3和cGMP的变化及其临床意义，为本文研究目的。应用镀铜镉还原法和放射免疫法检测患儿血清中NO的代谢产物NO_2／NO_3和cGMP含量。结果表明：小儿急性白血病急性期血清NO_2／NO_3和cGMP的含量明显高于正常对照组和完全缓解期组（P＜0．01）；急性淋巴细胞白血病与急性非淋巴细胞白血病相比无显著性差异（P＞0．05）。完全缓解期组与正常对照组相比，无显著性差异（P＞0．05）。结论：血清NO的检测可用于判断小儿急性白血的病情和监测化疗效果的指标之一，揭示了临床选用NO的细胞毒性作用可能为小儿急性白血病的治疗提供新的方法。To study the change of serum nitric oxide (NO) children with acute leukemia audits clinicalsignificance. using methods of serum nitrate/nitrite (NO/NO ) and cyclic guanosinemonophosphate (cGMP)in patients and normal subjects were measured with. copper-coatedcadium reduction method and radioimmunoassay. Results showed serum NO/NO and cGMPin patient group at acute stage were significantly higher than those in mormal subjects groupand completely recovery stage group (P<0. 01). There was not satistical difference betweenacute lymphocytic leukemia and acute non--lymphocytic leukemia (P>0. 05). Conclusion: De-tecting serum NO may assist to judge the patients condition and be regarded as a index to assess the effect of chemotherapy. These results indicated that using selective cytotoxic effectof NO may provide a new stratege for the treatment of acute leukemia.

关 键 词：白血病 一氧化氮 儿童 急性 CGMP 

分 类 号：R733.71[医药卫生—肿瘤]