尿液葡萄糖二酸(UGA)作为药物性肝病诊断检测指标的评估  

The Assessment of UGA Measurement in Diagnosis of Drug-induced Hepatitis

作　　者：赵年丰[1] 张伟红[1] 赵允文[1] 马亦林[1] 

机构地区：[1]浙江医科大学附属第一医院传染病科

出　　处：《浙江医科大学学报》1998年第6期252-253,270,共3页

摘　　要：目的：对UGA作为药物性肝病诊断检测指标的价值作出评估。方法：以UGA检测、临床综合诊断及药物再投试验作联合平行或前后重叠试验，以药物再投试验作金标准，评估UGA的诊断价值。结果：药肝108例和各型病毒性肝炎150例中，UGA真阳性85例、假阳性23例，假阴性23例，真阴性127例。敏感性78．70％、特异性84．67％、漏诊率21．29％、误诊率15．33％，拟然比5．14，阳性符合率64．89％，阴性符合率73．41％，总符合率82．17，正确诊断指数0．64，可用度0．63。结论：UGA作为药物性肝病诊断检测指标，方法灵敏书异，结果较满意。Objective: To assess the value of UGA(urine glucaric acid) as a biochemical marker to diagnose drug-induced hepatitis. Methods =UGA measurement,clinical diagnosis and drug regiving test were performed in parallel or overlaping tests, with drug regiving test as the gold standard to assess the value of UGA measurement.Results: 108 cases of drug-induced hepatitis, 150 cases of viral hepatitis were included in the study. There were85 patients with true-positive result, 23 false-positive, 23 false-negative and 127 true negative. The sensitivitywas 78. 70%,specificity 84. 67 %,rate of missed diagnosis 21. 29 %, misdiagnosis rate 15. 33 %, likelihood rate is5. 14, positive-coincident rate 64. 89%, negative-coincident rate 73. 41 and total coincident rate 82. 17%,Youden's index 0. 64,and availability 0. 63. Conclusion:The method is sensitive,specific and satisfactory in diagnosing drug-induced hepatitis.

关 键 词：药物中毒性肝病 肝炎 诊断 葡萄糖二酸 尿 

分 类 号：R575.104[医药卫生—消化系统]