辐射对大鼠视交叉上核c-fos表达的影响  

Effect of Irradiation on c-fos Expression in Rat Suprachiasmatic Nuclei

作　　者：秦立强[1] 童建[1] 

机构地区：[1]苏州医学院劳动卫生学教研室,215007

出　　处：《苏州医学院学报》1998年第11期1115-1117,1141,共4页Acta Academiae Medicinae Suzhou

基　　金：国家自然科学基金

摘　　要：实验观察到视交叉上核（SCN）中c-fos化的表达具有昼夜市律性，0．5yγ射线辐照大鼠后，其SCN中Fos蛋白表达增高，其中以光照或更为明显，辐照后仍存在昼夜节律性。To study the effect of low - dose irradiation on c - fos expression in the rat suprachiasmatic nuclei and its possiblemechamisnl. At tive time points of a day, immunohistochemistry was used to observe the number of c- fos immunoreactivecells in control group and experimental group exposed to 0 .5 Gy γ - rays irradiation. The circadian rhythm was tested by thecosinor analysis. Whole body irradiation elevated level of the Fos protein in the nuclei, especially during the light period(P< 0. 01 ). The circadian rhythms of c - fos expression were found in both control group and irradiationgroup. The cosinor equation for control group was Y = 83. 99 + 38 .22 * Cos(Wt - 193. 86), and that for irradiation group was Y = 114 .20 + 67.36 - Cos(Wt - 198 .20). The low - dose irradiation couldenhance the expression of c - fos in SCN mainly during the lighttime. but not obvious effecl was shown on the circadian rhythm.

关 键 词：视交叉上核 大鼠 辐射 C-FOS基因 昼夜节律 

分 类 号：Q811.213[生物学—生物工程] R811.5[医药卫生—放射医学]