视网膜一步穿刺法植入视网膜下聚酰亚胺载片的实验研究  

Experimental Research on One-step Retinal Puncture Implantation of Sub-retinal Polyimide Film

作　　者：刘武[1] 刘芳[2] 莫宾[1] 李倩[1] 汪东生[1] 卢清君[1] 

机构地区：[1]首都医科大学附属北京同仁医院、北京同仁眼科中心、北京市眼科与视觉科学重点实验室 [2]河北省邢台市眼科医院

出　　处：《首都医科大学学报》2010年第1期36-38,共3页Journal of Capital Medical University

基　　金：国家自然科学基金(30571989)资助项目~~

摘　　要：目的探讨视网膜一步穿刺法植入视网膜下人工视觉载片的可行性。方法健康成年新西兰白兔24只,采用随机数字表法分为植入组和伪植入组,每组12只兔。玻璃体切除手术后,将聚酰亚胺(polyimide)载片通过直接穿刺视网膜植入到视网膜下腔,伪植入组于成功植入0.5 min后将载片取出。植入手术后15、30、60 d进行眼底照相和光学相干断层成像观察。结果所有载片均可成功植入至视网膜下腔。2组术中和观察期内无载片移位、视网膜脱离和眼内出血等合并症。植入组后期载片上方视网膜变薄,伪植入组视网膜厚度正常。结论视网膜一步穿刺法可安全有效地将视觉载片植入兔眼视网膜下腔。该方法适用于视网膜下人工视觉的短期研究。Objective To investigate the feasibility of one-step retinal puncture for the implantation of sub-retinal artificial vision films. Methods Twenty-four adult healthy New Zealand white rabbits were randomly divided into two groups： the implantation group（12 rabbits） and the sham-implantation group（12 rabbits）. A polyimide film was implanted into the subretinal space via direct retinal puncture after vitrectomy. The implanted film was removed half a minute later in the sham group. Fundus photography and optical coherence tomography were taken 15, 30 and 60 days postoperatively. Results The polyimide film was implanted successfully into the sub-retinal space in all eyes. During the operation and the fellow-up period, there were no any film shift and surgical complications such as retinal detachment and intraocular hemorrhages in both groups. The retina over the film thinned in the implantation group in the late period, while normal thickness was kept in the sham group. Conclusion One-step retinal puncture could implant the artificial vision film into the sub-retinal space safely and effectively. This new method may be suitable for the short-term research of sub-retinal artificial vision.

关 键 词：视网膜下 聚酰亚胺 兔 光学相干断层成像 

分 类 号：R779.63[医药卫生—眼科]