神经肽Y基因启动子多态性与缺血性脑卒中的相关性研究  

Association between Neuropeptide Y Gene Promoter Polymorphisms and Risk of Ischemic Stroke

作　　者：于楠楠[1] 谭兰[1] 郁金泰[1] 高思山[2] 宋敬卉[3] 马腾[4] 王乃东[3] 唐咏春[4] 张娜[1] 

机构地区：[1]青岛大学医学院附属青岛市立医院神经内科,266071 [2]青岛市黄岛区中医院内科,266500 [3]青岛大学医学院附属医院神经内科,266003 [4]青岛市海慈医院神经内科,266033

出　　处：《中国临床神经科学》2010年第1期19-23,共5页Chinese Journal of Clinical Neurosciences

摘　　要：目的:探讨神经肽Y(NPY)基因启动子多态性与缺血性脑卒中的相关性。方法:采用聚合酶链反应(PCR)及基因测序技术,对450例缺血性脑卒中患者及423名正常对照者NPY基因启动子-399T/C(rsl6147)基因型及等位基因频率进行检测。Logistic回归分析去除混杂因素影响,分析其与缺血性脑卒中发病的相关性。结果:脑卒中组NPY基因型和等位基因频率与正常对照组比差异有显著统计学意义,特别是在小动脉闭塞性脑卒中类型中。-399C等位基因与缺血性脑卒中存在相关性,是其重要危险因素(OR=2.398,95%CI=1.036～5.553,P=0.041)。结论:NPY基因启动子多态性可能与缺血性脑卒中的发病存在相关,具有-399C等位基因的个体发生缺血性脑卒中的风险可能显著增加。Aim： To define whether there is a relationship between neuropeptide Y（NPY） gene polymorphism and ischemic stroke in a Chinese Han population. Methods： The polymorphism -399T/C （rs 16147） in the promoter of NPY gene was analyzed in 450 patients of ischemic stroke and 423 controls of Chinese origin by using polymerase chain reaction and the products were directly sequenced. Multivariate logistic regression analysis was used to remove confounding variables. Results： There were significant differences in the frequency of NPY genotypes and alleles between the patients and controls, especially for the patients with the small-artery occlusion. -399C allele was found to associate with an increased risk of ischemic stroke （odds ratios/OR=2.398, 95%CI=1.036-5.553, P=0.041）. Conclusion： NPY gene promoter polymorphisms maybe associated with ischemic stroke. Allele C at the -399T/C position may rise the risk of the disease.

关 键 词：缺血性脑卒中 神经肽Y 基因多态性 

分 类 号：R743[医药卫生—神经病学与精神病学]