血清中睾酮和雌激素水平与中心性浆液性脉络膜视网膜病变的关系  

The relationship between the level of testosterone and estradiol in serum and central serous chorioretinopathy

作　　者：唐娜[1] 王敏 燕振国[2] 岳红云[1] 冯建宇[1] 卢卓锦[1] 

机构地区：[1]南方医科大学南方医院眼科,广州510515 [2]兰州军区兰州总医院眼科中心 [3]陕西省咸阳市第一人民医院眼科中心暨咸阳市眼科中心

出　　处：《中华眼底病杂志》2010年第1期55-57,共3页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的探讨血清中睾酮和雌激素水平与中心性浆液性脉络膜视网膜病变（CSC）发病的关系。方法回顾分析经临床表现、眼底检查及荧光素眼底血管造影（FFA）确诊为活动期CSC的200例患者的临床资料。同时选取与CSC患者年龄、性别相匹配的200名体检健康者作为对照组。抽取两组受试者肘静脉血，应用磁性均相酶标测CSC患者及对照组血清中睾酮和雌激素水平。采用t检验对检测结果进行统计学处理。结果与对照组相比，CSC组男性患者血清中睾酮与雌激素值均升高，其差异有统计学意义（t=2．804，2．913；P=0．010，0．008）；女性患者血清中睾酮与雌激素值也升高，其差异有统计学意义（t=2．078，2．807；P=0．049，0．010）。CSC组中男性患者雌激素／睾酮值明显高于女性患者雌激素／睾酮值，其差异有统计学意义（t=2．231，P=0．046）。结论CSC患者血清睾酮与雌激素明显升高，尤其是雌激素／睾酮值增高更明显；血清中雌激素、雌激素／睾酮增高可能是CSC的致病因素。Objective To investigate the relationship between the level of testosterone and estradiol in serum and central serous chorioretinopathy （CSC）. Methods The clinical data of 200 patients with active phase CSC who diagnosed by clinical manifestation, examination of fundus and fluorescence fundus angiography （FFA）, were retrospectively analyzed. Two hundreds healthy people were collected as a control group. The blood of ulnar vein was collected and the method of magnetic homogeneous enzyme immunoassay was used to detect the level of testosterone and estradiol in serum of two groups. The results were analyzed statistically by t-test. Results The values of testosterone and estradiol of male were all higher in CSC group than that in control gro up, the differences were statistical significance （ t = 2. 804,2.913 ; P = 0.010,0. 008） ; it was also higher in female（t=2. 078,2. 807;P=0. 049,0. 010）. The value of testosterone/estradiol of male was higher than that of female in CSC group, the difference was statistical significance （t=2. 231, P = 0. 046）. Conclusions The level of testosterone and estradiol in serum of CSC group increased obviously, especially the value of testosterone/estradiol. The increase of estradiol and testosterone/estradiol may be an etiological factor of CSC.

关 键 词：脉络膜视网膜炎/病因学 雌激素类 睾酮 

分 类 号：R774.1[医药卫生—眼科]