溶血磷脂酸在消化系肿瘤中的作用  

Recent advances in understanding the role of lysophosphatidic acid in the pathogenesis of gastrointestinal tumors

作　　者：钟月圆[1] 黄杰安[1] 

机构地区：[1]广西医科大学第一附属医院消化内科,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2010年第3期276-279,共4页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30760275;广西科学基金资助项目;No.0832008~~

摘　　要：溶血磷脂酸是一种细胞间磷脂类信号分子,通过G蛋白偶联受体参与多种肿瘤的发生和发展,本文就溶血磷脂酸的结构及生物学作用在消化系肿瘤发生、发展中的作用机制进行探讨.Lysophosphatidic acid is an important intercellular lipid mediator that acts through G-protein coupled receptors to mediate the development and progression of a variety of tumors.In this article, we will summarize the structure and physiological function of lysophosphatidic acid and review its role in the pathogenesis of colon cancer, gastric cancer, liver cancer and other gastrointestinal tumors.

关 键 词：溶血磷脂酸 消化系肿瘤 G蛋白偶联受体 

分 类 号：R735[医药卫生—肿瘤] R743.31[医药卫生—临床医学]