BSD2000深部热疗联合PT方案化疗在非小细胞肺癌中的应用  

BSD2000 Deep Hyperthermia Combined with Chemotherapy of PT regimen in Patients with Non-small Cell Lung Cancer

作　　者：杨孟祥[1] 赵军[1] 王彦文[1] 

机构地区：[1]山东省聊城市人民医院肿瘤内科,聊城252000

出　　处：《中国肺癌杂志》2010年第2期132-135,共4页Chinese Journal of Lung Cancer

摘　　要：背景与目的通过与PT方案单独化疗的对比观察,探讨BSD2000深部热疗联合PT方案化疗治疗非小细胞肺癌(non-small cell lung cancer,NSCLC)的方法,观察其近期疗效、毒副作用及生存质量改善率方面是否存在优势。方法选择NSCLC患者60例,随机分为治疗组和对照组,各30例。治疗组:紫杉醇(paclitaxel,PTX)135mg/m2ivdirp3h qd d1+顺铂(cisplatin,DDP)20mg/m2ivdirp qd d1-5,同时于d1、d4化疗结束后2h内进行BSD2000热疗机精确定位热疗1h,21天为1周期,共3周期。对照组:PTX135mg/m2ivdirp3h qd d1+DDP20mg/m2ivdirp qd d1-5,21天为1周期,共3周期,不进行热疗。对比两组的有效率、毒副作用及生存质量改善率。结果治疗组有效率、生存质量改善率分别为63.33%、76.67%,对照组分别为36.67%、40.00%,两组有效率及生存质量改善率有统计学差异(P<0.05)。主要毒副作用均为骨髓抑制和消化道反应,两组无统计学差异(P>0.05)。结论BSD2000深部热疗联合PT方案化疗治疗d可明显提高疗效,有效率及生存质量改善率优于单纯PT方案化疗,毒副作用可耐受。Background and objective The aim of this study is to determine the short-term efficacy,toxicity and the rate of life-quality improvement of BSD2000 deep hyperthermia combined with chemotherapy of PT regimen in patients with non-small cell lung cancer （NSCLC） by comparation with PT regimen alone.Methods Sixty patients with NSCLC were randomly divided into the treatment group and control group,with 30 each.The treatment group was treated with chemotherapy （paclitaxel：135mg/m2 ivdirp 3 h qd d1＋cisplatin： 20 mg/m2 ivdirp qd d1-5） in combination with BSD2000 deep hyperthermia,and hyperthermia was positioned precisely and maintained for 60 min （2 times a cycle： d1,4 after the end of chemotherapy within two hours）.The control group was treated with chemotherapy alone.Treatment response in both groups were evaluated as well as side-effects after 3 cycles.By observing the results,comparing response rate,toxic side effects and quality of life improvement rate in two groups.Results The efficiency and the rate of life-quality improvement in the treatment group were 63.33%,76.67% respectively,and 36.67%,40.00% in the control group respectively.There were significant differences between two groups （P0.05）.The main side-effects were myelosuppression and gastrointestinal reactions,no significant difference between two groups （P0.05）.Conclusion BSD2000 deep hyperthermia combined with chemotherapy in patients with NSCLC can significantly increase the efficacy,response rate and quality of life improvement and without increasing sideeffects compared to chemotherapy alone.

关 键 词：热疗 化疗 肺肿瘤 紫杉醇 顺铂 

分 类 号：R734.2[医药卫生—肿瘤]