胃肠平滑肌起搏功能研究的最新动态  

Advances in research on pacemaking function of gastrointestinal smooth muscle cells

作　　者：王佐妤[1] 许文燮[1] 

机构地区：[1]上海交通大学医学院,生理学上海市200240

出　　处：《世界华人消化杂志》2010年第4期319-323,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.10672103~~

摘　　要：胃肠道平滑肌具有自动节律性收缩的特性,对消化和吸收功能具有十分重要的生理意义,但目前尚未明确胃肠道平滑肌的起搏机制.本文综述了近几年关于胃肠道起搏机制研究的最新进展,从起搏细胞的分类、功能、起搏机制以及其与胃肠动力障碍性疾病的关系等方面做了阐述.胃肠道平滑肌起搏活动的异常是引发胃肠动力障碍性疾病的重要原因之一,因此,胃肠起搏机制的相关基础研究具有重要的临床意义.Gastrointestinal smooth muscle has spontaneous contractile activity, which is very important to digestion and absorption function. However, the pacemaking mechanism in gastrointestinal smooth muscle is still not clear. In this article, we review the recent advances in research on the mechanisms underlying gastrointestinal pacemaker activity. We summarize the classification, function and pacemaking mechanisms of pacemaker cells, and the relationship between pacemaker cells and gastrointestinal motility dysfunction. As abnormal pacemaking activity is often associated with gastrointestinal motility dysfunction, it is of great clinical significance to clarify the pacemaking mechanisms in the gastrointestinal tract.

关 键 词：胃肠道 CAJAL间质细胞 起搏电流 胃肠动力障碍性疾病 

分 类 号：R57[医药卫生—消化系统]