腺苷蛋氨酸治疗药物性淤胆型肝炎疗效观察  

The effect of ademetionine on patients with drug-induced cholestatic hepatitis

作　　者：周淑云[1] 崔英 

机构地区：[1]中国石油天然气集团公司中心医院感染科,河北廊坊065000 [2]长春市南关区医院,长春130042

出　　处：《临床肝胆病杂志》2010年第1期69-71,共3页Journal of Clinical Hepatology

摘　　要：目的探讨腺苷蛋氨酸对药物性淤胆型肝炎的疗效。方法将88例药物性淤疸型肝炎随机分为治疗组46和对照组42例,治疗组在一般保肝治疗基础上加用腺苷蛋氨酸1000毫克溶于5%葡萄糖液250毫升每日1次静点,对照组仅给予一般保肝治疗,疗程均4周。结果治疗2周时,治疗组有效率明显高于对照组,两组间的差异有统计学意义(P<0.05)。治疗4周时,治疗组与对照组的有效率差异无统计学意义(P>0.05),但两组的临床治愈率的差异有统计学意义(P<0.05)。结论腺苷蛋氨酸在治疗药物性淤胆型肝炎上有较好疗效,能较早促进损伤的肝细胞修复、再生以缓解症状、体征及肝功恢复,是目前较理想的治疗药物性淤胆型肝炎的药物。Objective To investigate the effect of ademetionine on patients with cholestatic hepatitis induced by drugs.Methods 88 patients with drug induced cholestatic hepatitis were randomly divided into control group（n =42） and treatment group（n=46）.The liver protectant therapy combined with ademetionine 1000 mg in 5% glucose solution of 250 ml were given intravenously per day in treatment group for 4 weeks.The control group received liver protectant therapy only.Results The combined treatment was more effective in the treatment group than the control group after 2 weeks of treatment（P〈 0.05）.At the 4th week of treatment there was no significance difference between the two groups（P〈 0.05）.However,the recovery rate difference was statistically significant between the two groups（P〈 0.05）.Conclusion Ademetionine is effective and safe,in the treatment of patients with drug-induced cholestatic hepatitis,in promoting the liver metabolism and repairing the hepatic cell.

关 键 词：腺苷蛋氨酸 淤胆型 药物性肝炎 

分 类 号：R575.1[医药卫生—消化系统]