基因多态性预测结直肠癌化疗效果和不良反应  

Gene polymorphisms predict efficacy and toxicity of chemotherapy for colorectal cancer

作　　者：黄佳莹[1] 张文[1] 

机构地区：[1]复旦大学附属肿瘤医院肿瘤内科,复旦大学上海医学院肿瘤学系,上海200032

出　　处：《肿瘤》2010年第2期164-169,共6页Tumor

摘　　要：肿瘤患者个体之间存在化疗效果和不良反应的差异,如果仅仅根据个体的临床特征和病理特征指导治疗,已无法满足优化肿瘤治疗的要求。根据个体基因特征进行个体化治疗正日益受到关注。基因多态性是导致个体之间化疗反应差异的重要物质基础。基因多态性可以通过影响其相应蛋白的表达或活性,降低化疗药物的疗效或加重不良反应。近年来,在结直肠癌化疗方面的研究发现,参与药物代谢、转运和失活的多种蛋白,其相应基因的多态性位点可能会影响化疗效果和不良反应。因此,明确这些基因多态性位点对于实现肿瘤的个体化治疗具有重要意义。Objective：The efficacy and toxicity of anticancer drugs differ in different tumor patients. It could not meet the requirements of optimization of tumor treatment if only under the guidance of clinical and pathologic characteristics. More and more attention is focused on individualized therapy based on individual gene profiles. It has been identified that gene polymorphisms are responsible for different outcomes of individuals. Gene polymorphisms,including sequence polymorphism and single nucleotide polymorphism,will decrease the clinical efficacy of chemotherapeutic drugs or increase adverse reactions by influencing the expression or activity of the corresponding proteins. In recent years several gene polymorphisms related to drug metabolism,transportation,or inactivation may affect the outcomes of chemotherapy and the frequency of adverse reactions. Identification of the polymorphism genes is important for individual therapy for tumor patients.

关 键 词：结直肠肿瘤 多态现象 遗传 多态性 单核苷酸 药物治疗 预后 

分 类 号：R735.3[医药卫生—肿瘤] R730.53[医药卫生—临床医学]