比较SPECT—CT和PET—CT在小动物模型中的应用  

Comparison SPECT-CT with PET-CT in several applications of small-animal models

作　　者：潘懿范[1] 宋少莉[1] 黄钢[1] 

机构地区：[1]上海交通大学医学院附属仁济医院核医学科,200127

出　　处：《国际放射医学核医学杂志》2009年第4期196-199,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：上海市重点学科建设项目（S30203）;上海市科委重点项目（07JC14039）

摘　　要：在医学研究中，针对疾病的小动物模型进行动态生物学进程的监测已成为最重要的研究方法之一。传统核医学影像测得的重要生理学参数包括血流量、生化代谢和细胞受体等。而如今，核医学已发展至双元融合的影像模式，包括SPECT-CT和PET-CT，这意味着在同一次扫描中，通过硬件对图像的融合，可得到功能学和解剖学的双重影像。该文针对SPECT—CT和PET—CT在小动物模型中的应用进行了比较，结论：针对小动物模型的PET—CT在医学研究中的应用具有很大优势，但SPECT—CT仍有着非常重要的作用，而且研究成本低。With the development of medical science, monitoring dynamic biologic processes in small- animal models of diseases has become one of the most important approaches in medical studies. Important physiologic parameters that traditionally have been characterized by nuclear medicine imaging include blood flow, biochemical metabolism, and cellular receptors. Recently, nuclear medicine has been greatly facilitated by the newer development of dual-modality integrated imaging systems （SPECT-CT and PET-CT） , which provide functional and anatomical images in the same scanning session, with the acquired images coregistered by means of the hardware. The purpose of this review is to compare SPECT-CT with PET-CT in several applications of small-animal models. Conelusien： PET-CT for small animal modes in nledical research in the applications has great advantages, but SPECT-CT is still a very important role, and research low cost.

关 键 词：模型 动物 正电子发射断层显像术 体层摄影术 发射型计算机 单光子 体层摄影术 X线计算机 

分 类 号：R-332[医药卫生]