肿瘤血清标志物在乳腺癌诊断中的意义  

CIinicaI significance of 5 serum markers in diagnosis of breast cancer

作　　者：高洪波[1] 巩平[2] 李娜[2] 郭宁[1] 费晶[2] 黄伟[2] 王振华[3] 

机构地区：[1]石河子大学医学院,新疆石河子832002 [2]石河子大学医学院第一附属医院肿瘤内科,新疆石河子832002 [3]石河子大学药学院,新疆石河子832008

出　　处：《现代生物医学进展》2009年第23期4531-4533,4503,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨血清标志物CEA、CA15-3、CA12-5、TPS和VEGF不同组合在乳腺癌诊断中的临床应用价值。方法:用ELISA法分别检测53例乳腺癌患者、50例乳腺良性肿瘤及50例正常女性血清CEA、CA15-3、CA12-5、TPS和VEGF水平。结果:乳腺癌患者血清5种标志物的水平均较良性疾病组及正常对照组高,差异有统计学意义。CEA、CA15-3、CA12-5、TPS和VEGF对乳腺癌诊断的阳性率分别为30.2%、26.4%、37.75%、56.6%、35.8%,各种组合检测中,TPS与CA15-3联合检测阳性率可达到71.7%。结论:血清标志物中TPS与CA15-3联合检测是筛查乳腺癌的较好的组合,可以互相弥补单一指标的不足,以互补的方式较为显著地提高乳腺癌的检出率。Objective：To investigate the clinical value of detecting five serum marker：CEA,CA15-3,CA12-5,TPS and VEGF in different combination for diagnosis of breast cancer.Methods：The five serum markers were detected by enzyme linked immunosorbent assay in 53 cases of breast cancer and 50 cases of benign breast diseases and 50 cases in normal control group.Results：The serum levels of 5 tumor markers in breast cancer patients were significantly higher than those in the benign breast disease in the control group.the sensitivity of breast cancer by detecting the serum markers respectively was 56.6%,35.8%,30.2%,26.4%and 37.75%,and that was 71.7% by TPS plus CA15-3.Conclusion：The serum markers CEA,CA15-3,CA12-5,TPSandVEGF were much more sensitive markers,and the combined detection of CA15-3 and TPS was an effective method in screening breast cancer and their combined detection can significantly improve the sensitivity of breast cancer diagnosis.

关 键 词：乳腺癌 肿瘤标志物 CEA、CA15-3、CA12-5、TPS、VEGF 

分 类 号：R737.9[医药卫生—肿瘤] R730.3[医药卫生—临床医学]