肿瘤多药耐药性中的ABC转运蛋白及其调节  

The Involvement and Modulation of ABC Transporters in Multidrug Resistance

作　　者：黄九九[1] 洪梅[1] 

机构地区：[1]华南农业大学生命科学学院,广东广州510642

出　　处：《现代生物医学进展》2009年第23期4571-4573,4580,共4页Progress in Modern Biomedicine

摘　　要：ABC转运蛋白是一类利用ATP水解能量,逆浓度方向将一系列化合物转运通过膜结构的膜蛋白。这一类蛋白能转运离子,糖,氨基酸,维生素,多肽,多糖,激素,脂类及生物异源物质。P-糖蛋白(P-gp)、多药耐药相关蛋白(MRP)和乳腺癌耐药蛋白(BCRP)等ABC转运蛋白还具有转运抗癌药物的能力,因此对化疗的有效性有负面的影响。近年来,许多研究涉及到如何逆转由ABC转运蛋白引起的肿瘤多药耐药性。本文概述了近年来在蛋白水平,mRNA水平或DNA水平上对ABC转运蛋白调控的研究。ABC transporters are a family of membrane proteins that utilize the energy generated by ATP hydrolysis and transport a variety of compounds through membranes against steep concentration gradients.ABC transporters contain multidomain across cell membrane,they are found to be able to transport molecules such as ions,sugars,amino acids,vitamins,peptides,polysaccharides, hormones,lipids and xenobiotics.Moreover,ABC transporters such as P-gp,MRP and BCRP are involved in anticancer drug resistance and thus affect the efficacy of chemotherapy compounds.In recent years,many attempts have been made to reverse the process of multidrug resistance（MDR）.The modulation of ABC transporters in protein,mRNA and DNA levels to reverse MDR were summarized.

关 键 词：ABC转运蛋白 多药耐药性 ABC转运蛋白的调节方式 

分 类 号：R730.531[医药卫生—肿瘤]