“肾藏志应恐”有关神经生物学机制的研究思路  

Study strategies for neurobiology mechanism of "kidney storing will and responding to fear"

作　　者：刘书考[1] 严灿[1] 吴丽丽[1] 潘毅[1] 

机构地区：[1]广州中医药大学基础医学院中医基础理论教研室,广东广州510006

出　　处：《中西医结合学报》2010年第2期106-110,共5页Journal of Chinese Integrative Medicine

基　　金：国家自然科学基金资助项目(No.30873207)

摘　　要：中医理论认为,肾中精气是脑的形成、发育和功能发挥以及维持整个人体精神活动与行为活动的物质基础,同时也是情志活动的物质基础。中医情志学说认为"肾藏志,在志为恐",肾所藏之"志"的主要含义之一就是指记忆,包括了识记、保存和回忆3个基本环节。而现代医学则认为精神应激作为一种信息会在中枢神经系统留下相当于记忆的生物性"痕迹"。作者结合中医理论以及现代心理应激理论,从情志活动调控的角度,以中医情志学说为指导,以机体的恐惧反应记忆为切入点,提出依据"从病理药效推导生理"的研究思路,结合恐惧记忆的形成、巩固、提取和消退以及杏仁核-海马-前额叶皮质神经通路的可塑性,结合补肾方药的药理学效应,阐述恐伤肾的病理机制,并揭示肾(肾精)调控情志活动的物质基础、作用方式与神经生物学机制。The theory of traditional Chinese medicine （TCM） deems that kidney essence is the material basis of formation, development and function of the brain and it maintains human being＇s psychomotility and behavior. Moreover, kidney essence is the material basis of emotional activity. The emotion theory in TCM deems that kidney stores will and responds to fear. The so called will in this theory refers to memory which includes three basic steps such as memorization, storage and recollection. Meanwhile, Western medicine considers stress as a kind of information that forms memory trace in central nervous system. Combining the TCM theory with the modern psychological theory on stress, and from the points of views of the emotion regulation, the formation, consolidation, extraction and extinction of fear memory, and the plasticity of amygdala-hippocampus-prefrontal cortex nervous pathway, as well as the results of pharmacological studies of prescriptions and herbs for invigorating the kidney, the authors explained in this article the pathological mechanisms of kidney deficiency due to attack of fear, and revealed the material basis, the action modes, and the neurobiological mechanisms of the kidney in controlling and regulating emotional activity.

关 键 词：肾气 精(中医) 情志(中医病因) 恐惧 记忆 

分 类 号：R228[医药卫生—中医基础理论]